海南医学院学报2017，Vol.23Issue(23)：3327-3330,4.DOI:10.13210/j.cnki.jhmu.20171127.014
舒芬太尼/芬太尼复合丙泊酚用于高血压脑出血微创引流术麻醉的效果比较
The effects of sufentanil/fentanyl combined with propofol on the anesthesia of minimally in-vasive drainage for hypertensive cerebral hemorrhage
摘要
Abstract
Objective:To compare the effects of sufentanil/fentanyl combined with propofol on the anesthesia of mini-mally invasive drainage for hypertensive cerebral hemorrhage. Methods:Patients with hypertensive cerebral hemorrhage who received minimally invasive drainage in Huanggang Cerebrovascular Hospital between June 2014 and February 2017 were se-lected and randomly divided into two groups,observation group received sufentanil combined with propofol anesthesia,and control group received fentanyl combined with propofol anesthesia. The serum contents of nerve injury,stress response,oxida-tion reaction and inflammatory response markers were measured during surgery and 12 hours after surgery. Results:During surgery and 12 hours after surgery,serum TF,NSE,GFAP,GLU,NE,E,ACTH,Cor,Ins,MDA,AOPP,8-OHdG, NO,ICAM-1,TNF-α,IL-6,IL-17 and IL-23 levels of observation group were significantly lower than those of control group. Conclusion:Sufentanil combined with propofol for minimally invasive drainage of hypertensive cerebral hemorrhage is more ef-fective than fentanyl combined with propofol to reduce the brain damage and inhibit the inflammatory response,stress response and oxidation reaction.关键词
高血压脑出血/舒芬太尼/脑损伤/炎症反应/氧化应激反应Key words
hypertensive cerebral hemorrhage/sufentanil/brain damage/inflammatory response/oxidative stress re-sponse分类
医药卫生引用本文复制引用
邱琼,王小红,南桂丽..舒芬太尼/芬太尼复合丙泊酚用于高血压脑出血微创引流术麻醉的效果比较[J].海南医学院学报,2017,23(23):3327-3330,4.基金项目
黄冈市科技一般项目(20151028X)This study was supported by Science and Technology General Project of Huanggang City(Grant No. 20151028X) （20151028X）
