解放军医药杂志2017，Vol.29Issue(12)：28-31,4.DOI:10.3969/j.issn.2095-140X.2017.12.008
腹腔镜与开腹直肠癌根治术对直肠癌患者机体炎症和免疫功能的影响
Effects of Laparoscopic and Open Radical Resection of Rectal Carcinoma on Inflammation and Immune Function of Patients with Rectal Cancer
摘要
Abstract
Objective To contrastively analyze effects of laparoscopic and open radical resection of rectal carcino-ma on inflammation and immune function of patients with rectal cancer. Methods Clinical data of 44 patients with rectal cancer admitted during March 2014 and December 2016 was included in the study, and the patients were divided into obser-vation group (n=22) and control group (n=22) according to different surgical methods. Observation group received lapa-roscopic radical resection, while control group received traditional open radical resection of rectal carcinoma. At preopera-tive 1 d and at postoperative 1st, 4th and 7thd, T-lymphocyte subsets, natural killer T (NKT) cells and natural killer (NK) cells levels were detect. Levels of interleukin-6 (IL-6) and IL-10 were detected at preoperative 1 d and at postoperative 1st d, and then intraoperative conditions were compared between two groups. Results Values of intraoperative intraoperative bleeding volume, postoperative anal exhaust time, eating time and total hospitalization time in observation group were signif-icantly lower those in control group (P<0. 05). At postoperative 1std, IL-6 levels were significantly lower, while IL-10 levels were significantly higher than those at preoperative 1 d in two groups (P<0. 05), and the change ranges in observa-tion group were significantly larger than those in control group (P<0. 05). At postoperative 1std, the differences in CD3+, CD4+, CD8+, CD4+/CD8+, NKT and NK cells were significant higher compared with those at preoperative 1 d between two groups (P<0. 05), and the change ranges in control group were significantly larger than those in observation group (P<0. 05). NK cells levels at postoperative 4thand 7thd in observation group were significantly higher than those in control group (P<0. 05). There was no significant difference in incidence rate of complications between two groups (P>0. 05). Conclusion Compared with those by open radical resection of rectal carcinoma, laparoscopic radical resection of rectal carcinoma may achieve little effect on cellular immune function, less inflammatory reaction and trauma and quickly postop-erative recovery, and therefore it is a safe and reliable method of minimally invasive surgery.关键词
腹腔镜/开腹直肠癌根治术/直肠肿瘤/炎症/免疫Key words
Laparoscopes/Open radical resection of rectal carcinoma/Rectal neoplasms/Inflammation/Im-munity分类
医药卫生引用本文复制引用
莫琳,刘保荣..腹腔镜与开腹直肠癌根治术对直肠癌患者机体炎症和免疫功能的影响[J].解放军医药杂志,2017,29(12):28-31,4.基金项目
陕西省自然科学研究计划项目(2014JM2-8182) （2014JM2-8182）
