中国实用神经疾病杂志2017，Vol.20Issue(21)：16-20,5.DOI:10.3969/j.issn.1673-5110.2017.21.004
帕金森病震颤和原发性震颤的电生理学特征研究
Analysis of the electrophysiological features of tremor and essential tremor in Parkinson's disease
摘要
Abstract
Objective To explore the electrophysiological differences between Parkinson ' s disease tremor (PT ) and essential tremor (ET) .Methods Fifty PT patients and 70 ET patients and 45 age-gender-matched healthy volunteers admitted in Department of Neurology ,the Second Affiliated Hospital of Zhejiang University School of Medicine from May 2015 to April 2016 were included .Clinical data and tremor analyses under different postures were obtained .All patients were evaluated with tremor scores and accelerometry in resting ,postural and loading states .The amplitude ,frequency and frequency dispersion of rest tremor , postural tremor and the influence of weight on tremor were retrospectively analyzed and compared .Results The amplitude:Both PT amplitudes and ET amplitudes in loading states were higher than those in rest state (P<0.05) ,healthy volunteers'amplitudes in loading states were similar to those in rest state .The frequencies of all patients in loading states were faster than those in rest state ,and there were statistically significant differences in control group ,but there were not statistically significant differences in PD group and ET group .Conclusion We found that the tremor parameters measured by the accelerometry can not be used to dis-tinguish PD and ET patients ,but can be used to distinguish pathological tremor and physiological tremor .关键词
帕金森病/原发性震颤/加速度传感器/震颤幅度/峰值频率/频谱宽度Key words
Parkinson's disease/Essential tremor/Accelerometry/Amplitude/Center frequency/Frequency dispersion分类
医药卫生引用本文复制引用
徐从英,张晓玲,官俏兵,沈宇菲,王琰萍..帕金森病震颤和原发性震颤的电生理学特征研究[J].中国实用神经疾病杂志,2017,20(21):16-20,5.基金项目
浙江省医药卫生科技计划项目(2016KYB293) （2016KYB293）
