中国实用神经疾病杂志2017，Vol.20Issue(23)：1-5,5.DOI:10.3969/j.issn.1673-5110.2017.23.001
白藜芦醇对阿尔茨海默病合并糖尿病大鼠的氧化应激作用
Effects of resveratrol on the memory impairment and oxidative stress in rat model of Alzheimer's disease with dia-betes mellitus
摘要
Abstract
Objective To investigate the effects of resveratrol on memory impairment and oxidative stress in the rat model of Alzheimer's disease with diabetes mellitus .Methods We used the streptozotocin intraperitoneal injection and then Aβ1-40 hipp-ocampal injection to establish the Alzheimer's disease with diabetic rat model .The spatial learning and memory performance were tested by the Morris water maze ,we also examined the activity of acetylcholinesterase (AchE) ,choline acetyltransferase (ChAT) , malondialdehyde(MDA) ,superoxide dismutase (SOD) and glutathione (GSH) in cortex and hippocampus .Results The results showed that resveratrol could successfully inhibit the memory impairment ,increase the ChAT ,SOD and GSH activity ,decrease the AchE and MDA activity in diabetic with Alzheimer's disease rat model .Conclusion Resveratrol can protect the Alzheimer's disease with Diabetic rat model by decreasing memory impairment and oxidative stress .关键词
阿尔茨海默病/白藜芦醇/氧化应激/糖尿病/大鼠/乙酰胆碱酯酶(AchE)/胆碱乙酰转移酶(ChAT)/丙二醛(MDA)/超氧化物歧化酶(SOD)/谷胱甘肽(GSH)Key words
Alzheimer' s disease/Resveratrol/Oxidative stress/Diabetes mellitus/Rats/Acetylcholinesterase (AchE )/Choline acetyltransferase(ChAT)/Malondialdehyde(MDA)/Superoxide dismutase(SOD)/Glutathione(GSH)分类
医药卫生引用本文复制引用
孙治坤,马兴荣,韩笑,张钱林,张杰文..白藜芦醇对阿尔茨海默病合并糖尿病大鼠的氧化应激作用[J].中国实用神经疾病杂志,2017,20(23):1-5,5.基金项目
河南省医学普通科技攻关资助项目(201503154) （201503154）
