中国实用神经疾病杂志2017，Vol.20Issue(23)：14-18,5.DOI:10.3969/j.issn.1673-5110.2017.23.004
帕金森病异质性与自主神经症状关联分析
Analysis of the relationship between Parkinson's disease heterogeneity and autonomic symptoms
摘要
Abstract
Objective We analyzed the characteristics of autonomic symptoms in PD patients and the correlation between the clinical heterogeneity of PD and autonomic symptoms .Methods We recruited 121 Parkinson's disease patients in our study . Patients's autonomic symptoms were assessed by using the scale outcomes in PD for autonomic symptoms (SCOPA-AUT) .Hoe-hn-Yahr (H-Y) was used to describe the progress of PD symptoms .Based on the H-Y classification ,patients were allocated into the early ,middle and late stage groups .Based on the course of disease ,patients were allocated into three groups ,≤2 years ,2-5 years and more than 5 years .Based on the age of symptom onset ,patients were allocated into early onset group (≤50 years old) and late onset group (>50 years old) .Based on gender ,patients were allocated into male and female groups .Finally ,according to the performance of motor disorders ,patients were divided into mixed group ,tremor group and rigid group .Results 98.3% of the PD patients recruited suffered at least one of autonomic symptoms .SCOPA-AUT score showed that the digestive system symp-toms and urinary system dysfunction were the most frequent and the most severe lesion .Compared of three subtypes of PD based on the H-Y classification and another three based on the course of disease ,there were significant statistical difference in H-Y clas-sification ,the course of disease and SCOPA-AUT score .There was no significant difference in SCOPA-AUT score between those groups ,which were divided based on the age of onset ,gender ,and the performance of motor disorders .The symptoms of autonomic symptoms were milder in female than in male .Conclusion Autonomic dysfunction is common in PD patients .Autonomic dysfunc-tion become more serious with the course of disease .Female maybe a protective factor of the autonomic system in PD patients .关键词
帕金森病/异质性/自主神经功能障碍/H-Y分级/女性Key words
Parkinson's disease/Heterogeneity/Autonomic symptoms/H-Y classification/Female分类
医药卫生引用本文复制引用
李蒙燕,郑浩,陈浩博..帕金森病异质性与自主神经症状关联分析[J].中国实用神经疾病杂志,2017,20(23):14-18,5.基金项目
广州市医药卫生科技项目,编号:20171A010247 （）
