中国实用神经疾病杂志2017，Vol.20Issue(23)：24-28,5.DOI:10.3969/j.issn.1673-5110.2017.23.006
认知康复训练联合盐酸多奈哌齐对脑卒中后认知障碍P 300的影响
Effect of cognitive rehabilitation combined with donepezil on P 300 potential of post-stroke cognitive impairment
摘要
Abstract
Objective To observe the effects of cognitive rehabilitation combined with donepezil on P 300 potential of post-stroke cognitive impairment(PSCI) .Methods Forty-four patients with PSCI were randomly divided into medicine group (24 cases) and control group (20 cases) .All participants were adults (28 male and 16 female;mean age 63.58 ± 10.37 ) .Patients in both groups were given cognitive rehabilitation training for 1 month ,and the patients in medicine group were treated with donepezil 5mg/d for 1 month in addition .All patients with PSCI were assessed by Montreal cognitive assessment scale (MoCA) ,auditory e-vent-related potentials P300 before and after 1 month treatments .Results After 1 month treatment ,both groups obtained remark-able higher scores in MoCA than those before treatments (P<0.05) .Compared to control group ,the increase of MoCA improve-ment in medicine group was much more imposing ,especially in vision orientation and executive function (P<0.01) and concentra-tion and delayed memory (P<0.05) .P300 latency of control group was shorten than before(P<0.05) .Compared with the two group after treatment ,P300 latency in medicine group was shorten (P<0.05) ,and P300 amplitude was obviously higher (P<0.01) ,which was statistically significant .Conclusion Compared with cognitive rehabilitation only ,cognitive rehabilitation combined with donepezil has better effect in patients with PSCI .关键词
多奈哌齐/卒中后认知障碍/P300电位/事件相关电位/MoCA评分Key words
Donepezil/Post-stroke cognitive impairment/P300 potential/Event-related potentials/MoCA score分类
医药卫生引用本文复制引用
刘玲玉,范俐,张红,MOHAMMADALI Soleimani Damaneh..认知康复训练联合盐酸多奈哌齐对脑卒中后认知障碍P 300的影响[J].中国实用神经疾病杂志,2017,20(23):24-28,5.基金项目
上海市残联课题(YZ2015002) （YZ2015002）
