中国实用神经疾病杂志2017，Vol.20Issue(23)：39-42,4.DOI:10.3969/j.issn.1673-5110.2017.23.010
高同型半胱氨酸血症与糖尿病合并血管性痴呆的相关性分析
Correlation between hyperhomocysteinemia and vascular dementia in diabetes mellitus
摘要
Abstract
Objective To investigate the correlation between dementia hyperhomocysteinemia and diabetic vascular .Methods Totally 60 diabetic patients with vascular dementia ,60 patients with vascular cognitive impairment no dementia and 60 patients with simple diabetes were selected as dementia group ,cognitive impairment group and control group ,respectively .The mini mental state scale and the Montreal cognitive assessment scale were used to assess the cognitive function score .The plasma homocysteine levels were determined ,and the plasma homocysteine levels and incidence of hyperhomocysteinemia were compared among the three groups .According to hyperhomocysteinemia prevalence ,each group was divided into A group (high homocysteine) ,B group (non hyperhomocysteinemia) ,their cognitive function scores were compared .Results The MMSE score ,MoCA score difference of three groups were statistically significant (P<0.05);the levels of homocysteine ,homocysteine incidence of three groups were sta-tistically different (P<0.05) .MMSE score and MoCA score in A group were lower than those of B group (P<0.05) .Hyperho-mocysteinemia was closely related to diabetic combined with vascular dementia (r=0.809 ,P<0.05) .Conclusion Hyperhomocys-teinemia is closely related to diabetes mellitus and vascular dementia .The higher of the homocysteine level ,the worse of the cogni-tive impairment .关键词
糖尿病/血管性痴呆/高同型半胱氨酸血症/认知功能/相关性Key words
Diabetes mellitus/Vascular dementia/Hyperhomocysteinemia/Cognitive function/Correlation分类
医药卫生引用本文复制引用
吴彩葵,方芳..高同型半胱氨酸血症与糖尿病合并血管性痴呆的相关性分析[J].中国实用神经疾病杂志,2017,20(23):39-42,4.基金项目
广西壮族自治区卫生和计划生育委员会自筹科研课题(Z20170052) （Z20170052）
