激光生物学报2017，Vol.26Issue(6)：540-543,4.DOI:10.3969/j.issn.1007-7146.2017.06.011
两亲性高分子功能化氧化石墨烯的制备与生物相容性评价
Fabrication and Biocompatibility Evaluation of Amphiphilic Polymer-decorated Graphene Oxide
摘要
Abstract
Two-dimensional graphene oxide ( GO) has low cytotoxicity and good biocompatibility, which can be employed as good photothermal/imaging agents as well as nanocarriers for the delivery of chemotherapeutic drugs/genes. However, there are strong Vander Waals forces among the layer of GO, which can cause deteriorating effects of the ag-glomeration of GO, and is unfavorable for biological applications. In this work, 1, 2-distearoyl-sn-glycero-3-phosphoeth-anolamine-peg-amine ( DSPE-PEG-NH2 ) was employed to decorate GO, affording hybrid GO nanoparticles, DSPE-PEG-GO. The well-dispersed DSPE-PEG-GO was kept stable in aqueous solution for even more than two weeks, and it had no obvious cytotoxicity, which is promising in biomedicine.关键词
氧化石墨烯/稳定性/生物相容性/生物医学Key words
graphene oxide/stability/biocompatibility/biomedicine分类
生物科学引用本文复制引用
王欢欢,胡祥龙..两亲性高分子功能化氧化石墨烯的制备与生物相容性评价[J].激光生物学报,2017,26(6):540-543,4.基金项目
国家自然科学基金面上项目(21674040) （21674040）
广东省杰出青年科学基金(2016A030306013) （2016A030306013）
国家自然科学基金青年项目(51403042) （51403042）
广东省特支计划科技创新青年拔尖人才(2015TQ01R604) （2015TQ01R604）
广东省自然科学基金(2014A030310310) （2014A030310310）
广州市科学研究专项基金(201607010328) （201607010328）
