水产学报2018，Vol.42Issue(1)：149-158,10.DOI:10.11964/jfc.20170410794
鱼类胰岛素、胰岛素受体和胰岛素受体底物的生物学特性 及其对营养物质代谢的调控
Biological characteristics of three key members of insulin signaling systems and their functions in regulation of nutrient metabolism in fish: A review
摘要
Abstract
Insulin is a member of peptide family and plays important roles in the regulation of nutrition metabol-ism in fish. To decipher the mechanism of insulin regulating nutrient metabolism, the present paper reviewed the progress involved in the structure and expression of three members (insulin, insulin receptor and insulin receptor substrate) of insulin signaling pathways, and the regulation of insulin in carbohydrate, lipid and protein metabol-ism. At present, although some progress has been made in study of the insulin signaling pathway, many basic ques-tions remain unknown and further investigations are needed: (1) studies involved in the functions of different iso-forms of insulin, insulin receptor and insulin receptor substrate; (2) molecular mechanism of insulin regulating nu-trient metabolism; (3) investigation into insulin signaling pathway and regulatory mechanism.关键词
鱼类/胰岛素/信号传递系统/生物学特征/营养物质代谢调控Key words
fish/insulin/signaling pathway/biological characteristics/nutrient metabolism分类
农业科技引用本文复制引用
罗智,卓梅琴..鱼类胰岛素、胰岛素受体和胰岛素受体底物的生物学特性 及其对营养物质代谢的调控[J].水产学报,2018,42(1):149-158,10.基金项目
国家自然科学基金(31422056) （31422056）
中央高校基本科研业务经费(2014JQ002,2662015PY017) （2014JQ002,2662015PY017）
National Natural Science Foundation of China (31422056) （31422056）
Fundamental Research Funds for the Central Universities, China (2014JQ002, 2662015PY017) （2014JQ002, 2662015PY017）
