世界中医药2017，Vol.12Issue(12)：2957-2960,4.DOI:10.3969/j.issn.1673-7202.2017.12.023
加味参芪寿胎汤治疗早期先兆流产合并亚临床甲减的临床疗效及其对外周血中HMGB1、RAGE细胞因子的影响
Curative Effect of Shenqi Shoutai Prescription in the Treatment of Early Phase Threatened Abortion Combined with Subclinical Hypothyroidism and its Effect on Cytokines of HMGB1 and RAGE in Peripheral Blood
摘要
Abstract
Objective:To observe the curative effect of Shenqi Shoutai prescription combined with euthyrox in treatment of the early phase threatened abortion with subclinical hypothyroidism and its effect on cytokines of HMGB 1 and RAGE in peripheral blood.Methods:A total of 78 cases of patients with early threatened abortion with subclinical hypothyroidism admitted into our hospital from March 2015 to March 2016 meeting the requirement of the research were selected.Then divided into study group and control group with 39 cases in each group.The study group was given Shenqi Shoutai prescription combined with euthyrox for treatment;and the control group was given progesterone Injection and euthyrox for treatment.The level changes of serum β-human chorionic gonadotropin,estradiol,progesterone,TSH and peripheral hematoma HMGB1 and RAGE for patients in two groups were compared.Results:After treatment,the positive rate of high mobility group protein B1 (high mobility group box 1 protein,HMGB1),advanced glycation end products ( receptor for advanced glycationend product receptor,RAGE) was superior to those of the control group and the comparison was of statistical significance (P<0.05).The total efficiency of the study group was 84.62%,which was higher than the 69.23%in the control group.The difference was of statistical significance (P<0.05).After treatment,the index of serum beta human chorionic gonadotropin (beta-Human chorionic gonadotrophin,P-HCG),estradiol (Estradiol2,E2),progesterone (Pro-gesterone,P) and thyroid stimulating hormone (Thyroid stimulating,hormone,TSH) was better than that of the control group.The comparison was of statistical significance ( P <0.05 ).Conclusion:Shenqi Shoutai Prescription combined with euthyrox in the treatment of early threatened abortion with subclinical hypothyroidism has significant clinical effect.It can help patients to improve clinical symptoms,maintain patients′corpus luteum,recover to normal gestation level,reduce thyroid hormone secretion,improve thyroid function,reduce the cytokines indexes of HMGB 1 and RAGE in peripheral blood,help the inflammatory medium secretion in the body,enhance immune capacity,fully regulate the body fluid and cellular immunity,and promote the relative balance of body immune state.关键词
早期先兆流产/亚临床甲减/加味参芪寿胎汤/高迁移率族蛋白B1/晚期糖基化终末产物受体Key words
Early phase threatened abortion/Subclinical hypothyroidism/Shenqi Shoutai prescription/HMGB1/RAGE分类
医药卫生引用本文复制引用
单其其格,关敬之,韩晓江..加味参芪寿胎汤治疗早期先兆流产合并亚临床甲减的临床疗效及其对外周血中HMGB1、RAGE细胞因子的影响[J].世界中医药,2017,12(12):2957-2960,4.基金项目
内蒙古医科大学青年创新基金项目(YKD2014QNCX029) （YKD2014QNCX029）
