世界中医药2017，Vol.12Issue(12)：3055-3057,3062,4.DOI:10.3969/j.issn.1673-7202.2017.12.049
芝麻木酚素对肾型高血压大鼠的降压作用及降压机制研究
Study on Antihypertensive Effect and Mechanism of Sesame Lignan on Renal Hypertensive Rats
摘要
Abstract
Objective:To study the antihypertensive effect and mechanism of Sesame Lignan ( SL ) on renal hypertensive rats.Methods:Male SD rats were selected as experimental animal and randomly divided into sham surgery group,model group and SL group.The model of renovascular hypertensive rats was established and given 10 mg/kg/d Sesame Lignan for intervention.After in-tervention,blood pressurelevels,oxidative stress and endothelial function were measured.Results:In 3 weeks,4 weeks,5 weeks and 6 weeks after intervention,MBP levels of model group were significantly higher than sham surgery group.MBP levels of SL group were significantly lower than model group;6 weeks after intervention,AOPP,MDA contents in kidney and AOPP,MDA,ET-1 contents in serum of model group were significantly higher than sham surgery group.SOD,GSH-Px contents in kidney and SOD,GSH-Px,NO contents in serum were significantly lower than sham surgery group;AOPP,MDA contents in kidney and AOPP,MDA,ET-1 contents in serum of LS group were significantly lower than model group.SOD,GSH-Px contents in kidney and SOD,GSH-Px,NO contents in serum were significantly higher than model group.Conclusion:Sesame Lignancan reduces blood pressure level of renal hypertensive rats by inhibiting oxidative stress and reducing vascular endothelium damage.关键词
芝麻木酚素/肾型高血压/氧化应激/内皮损伤Key words
Hypertension/Renal hypertension/Oxidative stress/Endothelial injury分类
医药卫生引用本文复制引用
胡晓恒,滕薇..芝麻木酚素对肾型高血压大鼠的降压作用及降压机制研究[J].世界中医药,2017,12(12):3055-3057,3062,4.基金项目
2013年陕西省科技计划项目(2013JQ2073) （2013JQ2073）
