世界中医药2017，Vol.12Issue(12)：3063-3067,5.DOI:10.3969/j.issn.1673-7202.2017.12.051
从高血压肝火亢盛证的应激变化探讨肝主疏泄的生物学基础
Discussion on Biological Basis of the Liver Governing Free Flow of Qi Based on Changes of Hypertension with Liver-fire Hyperactivity Syndrome Under Stress
摘要
Abstract
Objective:To observe the macro and physicochemical changes of hypertensive rats with live -fire hyperactivity syndrome under stress,to evaluate the effects of stress in the process of hypertension,expounds the theoretical basis of liver governing the free flow of qi.Methods:Stress with same intensity was given to hypertension rats with liver fire hyperactivity ( SHR 14-18 weeks old) and normal rats (Wistar at the same age).The blood pressure,irritability degree,behavior and content of Ang-II and NE in serum were dynamically meassured.The difference and correlation for multiple dimensions were analyzed.Results:The adaptability to stress of hypertensive rats with liver-fire hyperactivity was worse than normal rats.Compared with non-stress group of SHR,the pressure increased significantly (P<0.05),and score of irritability degree was higher (P<0.05).The contents of Ang-II and NE in the blood was increased (P<0.05),and 2 weeks after the stress stopped,the above indexes were still significantly higher than non-stress SHR (P<0.05).Although the indexes of normal Wistar Rats under stress increased (P<0.05),but compared with the SHR which appeared in the late stage of stress later,and the indicators returned to normal level 2 weeks after stress stopped,and there was no significant difference (P>0.05).Conclusion:In normal physiological conditions,liver function is nor-mal.The body can make adaptive response if affected by external stress in a certain extent,but under dysfunction of the liver,stress injury will occur,the mechanism of which may be related to the content increase of NE and Ang-II.关键词
高血压/肝火亢盛证/应激/肝主疏泄/生物学基础Key words
Hypertension/Liver-fire hyperactivity syndrome/Stress/Liver governing the free flow of qi/Biological basis分类
医药卫生引用本文复制引用
马雪玲,王伟,王田,刘婧玮,李雪丽,邓冬,薛晓兴,赵慧辉,王娟,陈建新..从高血压肝火亢盛证的应激变化探讨肝主疏泄的生物学基础[J].世界中医药,2017,12(12):3063-3067,5.基金项目
国家自然科学基金青年项目( 81503382 ) （ 81503382 ）
国家自然基金面上项目( 81473521 ) （ 81473521 ）
北京中医药大学中青年教师项目(面上项目) (2015-JYB-JSMS036) （面上项目）
国家重点基础研究发展计划(973计划)项目(2011CB505106) （973计划）
