世界中医药2017，Vol.12Issue(12)：3071-3073,3.DOI:10.3969/j.issn.1673-7202.2017.12.053
健脾安肠丸对腹泻型肠易激综合征结肠组织SP、VIP、CGRP的影响
Effects of Jianpi Anchang Pill on SP, VIP and CGRP in the Colon Tissue of Diarrhea-predominate Pattern Irritable Bowel Syndrome
摘要
Abstract
Objective:To study the effects of Jianpi Anchang pill on SP and VIP in the colon tissue of Diarrhea -predominate Pat-tern Irritable Bowel Syndrome ( IBS-D).Methods:The IBS-D rat model was established by gavage of Radix et Rhizoma Rhei and binding limbs.A total of 60 adult SD rats were randomly divided into 4 groups:normal group,model group,Jianpi Anchang pill high dose group and Jianpi Anchang pill low dose group and Pinaverium Bromide group.The contents of SP,VIP and CGRP in the rat colon tissue were determined by ELISA.Results:In the model group,fecal shape score was much higher than that of normal group (P<0.01),while the score values of Jianpi Anchang pill high dose group and Pinaverium Bromide group were lower than model group (P<0.01,P<0.05);High,low dose of Jianpi Anchang pill and Pinaverium Bromide could decrease the contents of SP ad VIP and enhance the contents of CGRP in colon tissue of the model rats.Conclusion:Jianpi Anchang Pill can effectively ease IBS-D,and its effects may be related to reduce the SP and VIP and increase CGRP release.关键词
健脾安肠丸/腹泻型肠易激综合征/SP/VIP/CGRPKey words
Jianpi Anchang Pill/Diarrhea-predominate Pattern Irritable Bowel Syndrome/SP/VIP/CGRP分类
医药卫生引用本文复制引用
王玉娟,刘维明,张梦宇,宋亚璐,杨莹,荀丽英,王欣,孙明江..健脾安肠丸对腹泻型肠易激综合征结肠组织SP、VIP、CGRP的影响[J].世界中医药,2017,12(12):3071-3073,3.基金项目
济南市科技发展计划项目(201112009) （201112009）
