世界中医药2017，Vol.12Issue(12)：3102-3105,4.DOI:10.3969/j.issn.1673-7202.2017.12.061
温针灸联合玻璃酸钠关节腔注射治疗膝骨关节炎疗效及对MMPs的影响
Efficacy of Warming Acupuncture Combined with Sodium Hyaluronate Intraarticular Injection in the Treatment of Osteoarthritis and the Influence on MMPs
摘要
Abstract
Objective:To explore the efficacy of warming acupuncture combined with sodium hyaluronate intraarticular injection in the treatment of osteoarthritis and the influence on matrix metalloproteinase ( MMPs).Methods:A total of 92 patients with osteoar-thritis who were tread in our hospital from February 2014 to August 2016 were selected and randomly divided into observation group (n=46) and control group (n=46).Control group were treated with sodium hyaluronate intraarticular injection,and observation group were treated with warming acupuncture on the basis of control group.Both groups were treated for 4 weeks continuously.The clinical efficacy of 2 groups were compared,and the levels of MMPs and the tissue inhibitor of MMPs,the inflammatory factors of synovial fluid before and after treatment in 2 groups were detected and compared;Visual analogue scale ( VAS) and Lysholm knee joint function score ( LKSS) were used to evaluate and compare the pain condition and knee joint function in 2 groups before and after treatment.Results:The clinical efficacy of observation group (97.83%) was significantly higher than control group (80.43%) (P<0.01).Compared with that before treatment,the levels of MMP-2,MMP-3,MMP-9,TIMP-1 and IL-2,TNF-αof synovial fluid all decreased after treatment,and observation group was lower than control group (P<0.01).Compared with before treatment,the VAS scores of 2 groups decreased after treatment,and observation group was lower than control group.The LKSS score of 2 groups increased after treatment,and observation group was higher than control group ( P<0.01 ).Conclusion:War-ming acupuncture combined sodium hyaluronate in the treatment of osteoarthritis can significantly reduce the levels of MMPs and the tissue inhibitor of MMPs,inflammatory factors of synovial fluid,eliminate relevant inflammation and pain symptoms,delay the articular cartilage′s damage,and the clinical efficacy is significantly better than sodium hyaluronate intraarticular injection alone.关键词
膝骨关节炎/温针灸/玻璃酸钠/腔内注射/疗效/MMPsKey words
Osteoarthritis/Warming acupuncture/Sodium hyaluronate/Intraarticular injection/Efficacy/MMPs分类
医药卫生引用本文复制引用
陈娟,沈娟,陈政,胡文浩..温针灸联合玻璃酸钠关节腔注射治疗膝骨关节炎疗效及对MMPs的影响[J].世界中医药,2017,12(12):3102-3105,4.基金项目
2016年南京医科大学科技发展基金项目(2016NJMU142) （2016NJMU142）
