实用医学杂志2017，Vol.33Issue(24)：4064-4068,5.DOI:10.3969/j.issn.1006-5725.2017.24.011
NQO1和iNOS在不同分子分型乳腺癌中的表达及其临床意义
Expressions of NQO1 and iNOS in different molecular subtypes of breast cancer and their clinical signifi-cance
摘要
Abstract
Objective To investigate the difference of iNOS and NQO1 in breast cancer with different mo-lecular subtypes and the correlation between clinical parameters,and to explore the clinical treatment of breast can-cer. Methods The data on 100 patients with breast cancer who had undergone modified radical mastectomy was retrospectively reviewed.Expressions of iNOS and NQO1 were detected by immunohistochemistry.Numeration data was processed using χ2test or Fisher′s exact test.Spearman correlation was applied to analyze different clinical mo-lecular pathological features.Results NQO1 expression was correlated with TNM staging and lymph node metasta-sis(χ2=6.603,4.938,P<0.05),and the expression rate of NQO1 in overexpressing of HER-2 was higher than that in type luminal A(χ2=8.341,P < 0.008). Expression of iNOS was related to expression of Ki-67,stage of TNM and lymph node metastasis(χ2=5.243,8.157,and 5.929,P<0.05),the expression rate of iNOS in lumi-nal A was significantly lower than that in type luminal B(χ2=7.990,P<0.008).Conclusions The expression of NQO1 and iNOS may be involved the process of oxidative stress associated with breast cancer,and it plays an im-portant role in the development of breast cancer. Different molecular level of oxidative stress between the types of breast cancer may be different,whose molecular mechanism needs to be further studied.关键词
乳腺癌/iNOS/NQO1/免疫组化/分子分型Key words
breast cancer/iNOS/NQO1/immunohistochemistry/molecular subtype引用本文复制引用
王坤戊,刘江波,田燕晓,刘德纯,米建强..NQO1和iNOS在不同分子分型乳腺癌中的表达及其临床意义[J].实用医学杂志,2017,33(24):4064-4068,5.基金项目
2015年度河南省医学科技攻关计划(编号:201504009) （编号:201504009）
河南科技大学第一附属医院博士科研启动基金(编号:0801-2014) （编号:0801-2014）
