西安交通大学学报（医学版）2018，Vol.39Issue(1)：22-25,115,5.DOI:10.7652/jdyxb201801006
盐酸吡咯列酮对血红素氧合酶-1在动脉粥样硬化模型兔主动脉表达的影响
Effects of piogiltazone on the expression of hemooxygenase-1 in aortic atherosclerosis plaque area in rabbits
摘要
Abstract
Objective To investigate the effects of piogiltazone on the expression of hemooxygenase-1 in aortic atherosclerosis plaque area in rabbits .Methods We randomly divided 36 Watanabe heritable hyperlipidemic rabbits into 3 groups:control group ,high-cholesterol diet group ,and high-cholesterol diet with pioglitazone [8 mg/(kg · d)] group ,with 12 in each .All the animals were fed for 12 weeks and then sacrificed .Rabbit aortic atherosclerosis pathological features were observed by Masson staining ;the expression of hemooxygenase-1 in aortic atherosclerosis plaque area in rabbits was detected by immunohistochemistry , real-time quantitative PCR and Western blot techniques .Results Hemooxygenase-1 expression was obvious in the smooth muscle in aortic vessels and atherosclerosis plaques in the three groups of rabbits . The expression of hemooxygenase-1 was lower in high-cholesterol diet with pioglitazone group than in high-cholesterol diet group and significantly higher than in control group (P<0 .05) .Conclusion Pioglitazone can slow down the progression of atherosclerosis by up-regulating the expression of hemooxygenase-1 .关键词
血红素氧合酶-1/盐酸吡格列酮/动脉粥样硬化/主动脉/兔Key words
hemooxygenase-1/pioglitazone/atherosclerosis/aorta/rabbit分类
医药卫生引用本文复制引用
潘军强,张殿新,孙超峰,杨进..盐酸吡咯列酮对血红素氧合酶-1在动脉粥样硬化模型兔主动脉表达的影响[J].西安交通大学学报（医学版）,2018,39(1):22-25,115,5.基金项目
国家自然科学基金资助项目(No.81270236)Supported by the National Natural Science Foundation of China (No.81270236) （No.81270236）
