西安交通大学学报（医学版）2018，Vol.39Issue(1)：140-145,6.DOI:10.7652/jdyxb201801030
IVIM扩散加权成像技术在进行性肌营养不良中的应用价值
The value of intravoxel incoherent motion diffusion weighted imaging in progressive muscular dystrophy
摘要
Abstract
Objective To explore the value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI ) in patients with progressive muscular dystrophy .Methods We enrolled 7 patients with known progressive muscular dystrophy (4 Becker muscle dystrophy ,BMD;3 limb-girdle muscle dystrophy ,LGMD) in this study .Both IVIM ,T1 WI and T2 STIR sequences were performed on both thighs of all the subjects .Slow ADC ,fast ADC and fraction of fast ADC (Ff ) were measured .Tl weighted images were used to assess the fat infiltration of their thigh muscles using a 0-5 modified version of Mercuri's scale .Slow ADC ,fast ADC and fraction of fast ADC (Ff) were compared among the fatty infiltration ,edematous muscle and unaffected muscle (neither edematous nor fatty infiltration muscles in patients ) .One-way analysis of variance was used for statistical analyses with a significance of P < 0 .05 . Results The mean slow ADC value of fatty infiltration . edematous muscle . and unaffected muscle was 0 .75+0.39,1 .14±0 .19,and 1.00±0 .11 (10 -3 mm2/s ) , respectively ( P < 0 .05 ) .The mean fast ADC value in the three groups was 7 .14±6 .51,13 .56±9 .67,and 4 .02±1.89 (10-3 mm2 /s ) , respectively (P< 0 .05 ) . There was no significant difference in the Ff values among the three groups ( P > 0 .05 ) .The mean slow ADC value in different grades of steatosis was 1 .00±0 .11, 0.98±0 .17, and 0 .50±0 .29 (10-3 mm2/s) , respectively ; the slow ADC value in heavy fat infiltration group differed significantly from that in the other two groups( P<0.05 ).Conclusion IVIM-DWI can be used to quantitatively evaluate the thigh diffusion and microcirculation characteristics of muscles in patients with PMD , make a quantitative analysis of edema and steatosis of the muscle .and reflect the degree of muscle steatosis .关键词
进行性肌营养不良/扩散加权成像/体素内不相干运动成像/磁共振成像Key words
progressive muscle dystrophy/diffusion weighted imaging/intravoxel incoherent motion/magnetic resonance imaging分类
医药卫生引用本文复制引用
丁宁宁,周丽,屈婷婷,卞益同,刘本寅,杨健..IVIM扩散加权成像技术在进行性肌营养不良中的应用价值[J].西安交通大学学报（医学版）,2018,39(1):140-145,6.基金项目
国家重点研发计划(No.2016YFC0100300) ,国家自然科学基金面上项目(No.81471631、No .81171317、No .51706178) ,教育部"新世纪优秀人才支持计划"(No.NCET-11-0438)与西安交通大学第一附属医院临床研究课题重点项目(No.XJTU1AF-CRF-2015-004)Supported by the National Key Research and Development Program of China (No.2016YFC0100300) ,National Natural Science Foundation of China (No.81471631 ,81171317 and 51706178) ,Program for New Century Excellent Talents in University (No. NCET-11-0438) and the Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University (No.XJTU1AF-CRF-2015-004 ) （No.2016YFC0100300）
