中国组织工程研究2017，Vol.21Issue(34)：5413-5417,5.DOI:10.3969/j.issn.2095-4344.2017.34.001
多孔钛合金支撑棒在踝关节损伤中的应用及生物力学性能
Application and biomechanical study of porous titanium alloy support rod in ankle joint injuries
摘要
Abstract
BACKGROUND: Studies have shown that titanium alloy with good biocompatibility can be easily processed and synthesized to produce a porous structure with suitable pore diameter, which shows desired outcomes in the treatment of ankle injury. Its mechanical performance, however, is yet unclear. OBJECTIVE: To investigate the effect and biomechanical properties of porous titanium alloy support rod in ankle joint injuries. METHODS: The lateral ligaments of the ankle were lifted and ripped violently using a hemostatic forceps to make ankle injury models in 30 healthy Beagle dogs. Animal models were randomized into two groups: control and experimental groups (n=15 per group). A three-dimensional model of porous titanium alloy rod was established by using CAD software, and it was input into the EBM S12 system. Ti6A14V powder was added into the machine and melted layer by layer, and then made into porous cylinder rods of 4 mm in diameter and 12 mm in length. The control group used conventional repair, and the experimental group underwent repair with porous titanium alloy support rod implantation. Degree of ankle swelling, excellent/good repair rate, and electrophysiological and biomechanical properties were compared between two groups. RESULTS AND CONCLUSION: Ipsilateral ankle circumference showed no difference between the two groups before treatment (P > 0.05), but after repair with porous titanium alloy support rod implantation, the experimental groups had significantly lower ipsilateral ankle circumference than the control group (P < 0.05). The excellent/good rate was also significantly higher in the experimental group than the control group at 3 months after repair (P < 0.05). For the somatosensory evoked potential and electromyogram of the affected lateral ligament of the ankle, significantly lower latency and significantly higher amplitude was found in the experimental group than the control group at 3 months after repair, though there was no significant difference between the two groups before repair (P > 0.05). Maximum perturbation, elastic disturbance and damage immunity had no significant difference between the two group (P > 0.05), while the experimental group had significantly increased maximum load, elastic load, failure load and stiffness coefficient compared with the control group (P < 0.05). Overall, the porous titanium alloy support rod can achieve good outcomes in the repair of ankle injury, and help to improve the biomechanical properties of the ankle.关键词
生物材料/骨生物材料/多孔钛合金支撑棒/踝关节损伤/CAD软件/三维模型/体感诱发电位/肌电图/微机控制电子万能试验机/修复效果/生物力学性能分类
医药卫生引用本文复制引用
李大成,付莹,陈望军,冯跨..多孔钛合金支撑棒在踝关节损伤中的应用及生物力学性能[J].中国组织工程研究,2017,21(34):5413-5417,5.基金项目
河北省卫生厅科研基金项目(20170108)the Scientific Research Fund of Hebei Provincial Department of Health, No. 20170108 （20170108）
