中国组织工程研究2017，Vol.21Issue(34)：5418-5422,5.DOI:10.3969/j.issn.2095-4344.2017.34.002
三维塑形钛板颞肌下修补颅骨缺损的安全及有效性:38例患者数据分析方案
Safety and efficacy of three-dimensional shaping of titanium plate in subtemporal repair of skull defects: study protocol for a data analysis of 38 patients
钱伟 1张卫 1金浩 1朱扬清 1邹煜1
作者信息
- 1. 南通大学附属吴江医院(苏州市吴江区第一人民医院)神经外科,江苏省苏州市 215200
- 折叠
摘要
Abstract
BACKGROUND: Skull damage is necessary after decompressive craniectomy. Previously used autologous bone, allogeneic bone, and organic material are associated with the risk of an unsatisfactory cosmetic outcome and infection. Titanium mesh is an ideal material for cranioplasty. Digital three-dimensional shaping of titanium mesh allows it to perfectly match the skull defect and can restore the anatomic appearance of the defective area.OBJECTIVE: To explore the safety and effectiveness of the three-dimensional shaping of titanium plate in subtemporal repair of skull defects.METHODS: We retrospectively analyzed the surgical and follow-up data of 38 patients with skull defects who underwent subtemporal repair using three-dimensional shaping of a titanium plate at the Department of Neurosurgery, Wujiang Hospital (The First People's Hospital of Wujiang District), Nantong University, China, from January 2015 to December 2016. The primary outcome measure was the incidence of complications within postoperative 12 months. The secondary outcome measures were the Glasgow outcome scale score, Karnofsky performance scale score, National Institutes of Health stroke scale score, and skull computed tomography scan results at 1, 6, 12, 18, and 24 months after repair. This trial was registered in the Chinese Clinical Trial Registry (identifier: ChiCTR-IOC-17012947) at October 11th, 2017. RESULTS AND CONCLUSION: Partial results have been obtained from 38 patients who have been followed up for 6 to 24 months. No complications or adverse reactions occurred. Skull computed tomography scan results revealed that the titanium mesh and nail were well fixed, the skull shape was symmetrical, and no subcutaneous effusion or intracranial hemorrhage occurred. Complications, neurological function, and imaging findings in patients with frontotemporal skull defects provide an experimental basis for three-dimensional shaping of titanium plates in subtemporal repair of frontotemporal defects.关键词
生物材料/骨生物材料/临床试验/三维塑形钛板/颞肌/颅骨缺损/安全性/有效性/回归性病例分析分类
医药卫生引用本文复制引用
钱伟,张卫,金浩,朱扬清,邹煜..三维塑形钛板颞肌下修补颅骨缺损的安全及有效性:38例患者数据分析方案[J].中国组织工程研究,2017,21(34):5418-5422,5.
