中国组织工程研究2017，Vol.21Issue(34)：5552-5557,6.DOI:10.3969/j.issn.2095-4344.2017.34.023
早期检测阿尔茨海默病的生物标志物新型仿生受体
Novel bio-mimetic receptors for early detection of Alzheimer's disease biomarkers
摘要
Abstract
BACKGROUND: It is still a problem to achieve early and accurate diagnosis of Alzheimer's disease, and delayed treatments often occur in a large number of patients because of late diagnosis or misdiagnosis. Therefore, the development and improvement of related bioanalytical methods are of great importance for the biomarker detection of Alzheimer's disease which is still lack of means that are sensitive, efficient and low-cost. OBJECTIVE: To summarize the diagnostic methods and related biomarkers of Alzheimer's disease, and to sum up the research progress in novel biomimetic receptors for the early detection of Alzheimer's disease biomarkers. METHODS: PubMed, CNKI and Wanfang databases were used to search articles related to the biomarker studies of Alzheimer's disease and relevant studies about methods of biomarkers detection published from 2000 to 2016. The key words were "Alzheimer's disease, biomarkers, detect/detecting/detection" in Chinese and English, respectively. Finally 40 articles were obtained for the review. RESULTS AND CONCLUSION: At present, the bioanalytical methods used for biomarker detection of Alzheimer's disease mostly utilize antibodies as recognition and capture elements of biomarkers, but there are some limitations using traditional antibodies as detection receptors. Thus, novel biomimetic receptors can be substituted for conventional antibodies. Novel biomimetic receptors have high specificity, small size, low production costs and high product stability, and their chemical modification process is relatively convenient. Biomimetic receptors developed for protein analysis include aptamers, polypeptide receptors, peptoid receptors, molecularly imprinted polymers, nanobodies, gelsolin and cucurbit urils. Detection of biomarkers with novel biomimetic receptors instead of conventional antibodies will be more accurate and timely in the early diagnosis of Alzheimer's disease.关键词
生物材料/阿尔茨海默病/生物标志物/仿生受体/生物检测/生物分析/早期诊断/传统抗体/捕捉元件分类
医药卫生引用本文复制引用
宿烽,云鹏,刘雪,沈鑫,李成龙,李荣烨..早期检测阿尔茨海默病的生物标志物新型仿生受体[J].中国组织工程研究,2017,21(34):5552-5557,6.基金项目
青岛市科技惠民专项(16-6-2-17-nsh) （16-6-2-17-nsh）
青岛科技大学"大学生创新创业训练计划"项目(201501004, 201601007)the Science and Technology Benefiting Policy of Qingdao, No. 16-6-2-17-nsh （201501004, 201601007）
College Students Innovation and Entrepreneurship Training Program in Qingdao University of Science and Technology, No. 201501004, 201601007 （）
