摘要
Abstract
Objective To explore the characteristics of moderate-severe acute attacks of bronchial asthma in children at school age and the correlation between the fractional exhaled nitric oxide (FeNO) and their lung function.Methods The clinical data of 120 children patients at school age with moderate-severe acute attacks of bronchial asthma to receive treatment in our hospital were collected (an observation group).Another 100 healthy children at school age who had received physical examination in our hospital in the same period were selected to constitute a control group.After admission,the two groups received bronchial stimulation test,FeNO detection and lung function examination to compare the above-mentioned indexes and analyze the correlation between FeNO and lung function in acute attacks of bronchial asthma.Results (1)In the observation group,male accounted for 63.33％;those with family history accounted for 20.00％,and allergic rhinitis 61.67％,passive smoking 42.50％,moderate asthma 75.83％ and primary attack of asthma 60.00％.In terms of allergens,mite accounted for 80.00％ and house dust 70.00％.The levels of total immunoglobulin E (IgE) in children patients were high.The onset seasons mainly were autumn and winter,and the incidence of associated pneumonia was 52.50％.(2)The levels of FeNO in the observation group were higher than those in the control group (P ＜ 0.05),the levels of FeNO in patients with moderate bronchial asthma were lower than those in severe children patients (P ＜ 0.05);(3)FeNo was negatively correlated with the percentage of forced expiratory volume in one second (FEV1％) (P ＜ 0.05) and was not significantly correlated with the percentage of the forced vital capacity (FVC) and the maximum expiratory flow (PEF) (PEF％) (P ＞ 0.05).Concluson The attacks of bronchial asthma in children at school age are common in autumn and winter and males and are often complicated with allergic rhinitis and pneumonia.The serum total IgE levels in children patients are high,and the FeNO expression levels in children patients are high and are negatively correlated with EFV1.关键词
支气管哮喘/学龄期/儿童/呼出气/一氧化氮/肺功能Key words
bronchial asthma/children at school age/FeNO/lung function分类
医药卫生
