中国医疗设备2018，Vol.33Issue(1)：1-5,15,6.DOI:10.3969/j.issn.1674-1633.2018.01.001
面向临床应用的光声成像技术
Photoacoustic Imaging Technology for Clinical Applications
摘要
Abstract
Photoacoustic imaging is a novel imaging modality that utilizes pulsed laser to illuminate samples and ultrasonic transducers for detection of the laser absorption generated ultrasonic/photoacoustic waves. Benefited from its high optical contrast and acoustic resolution at depth, as well as the capability of acquiring optical spectral information, photoacoustic imaging allows for structural and functional imaging of the biological relevant information such as hemoglobin concentration, blood oxygen metabolism, and lipid with high specificity, and is able to capture the corresponding physiological feature dynamics with high sensitivity. In terms of the imaging system, photoacoustic imaging manifests a variety of embodiments catering the multi-scale biomedical imaging needs. The above mentioned features and capabilities enable extensive biomedical application potentials of this imaging modality in both clinical diagnosis and pathological analysis, such as malignant tumor detection, atherosclerotic plaque assessment, and microcirculation abnormality diagnosis. Therefore, it is attracting more and more attention and interests in a wide range of biomedical research areas. This article presented the recent progress of photoacoustic technology development and application studies in our group in the fields of microvascular imaging, intravascular imaging, gastrointestinal endoscopic imaging, and sentinel lymph node imaging.关键词
光声成像/临床应用/光学分辨率/血管内成像/消化道内窥成像/前哨淋巴结成像Key words
photoacoustic imaging/clinical application/optical resolution/intravascular imaging/gastrointestinal endoscopy/sentinel lymph node imaging分类
生物科学引用本文复制引用
林日强,冷吉,陈敬钦,刘成波,龚小竞,宋亮..面向临床应用的光声成像技术[J].中国医疗设备,2018,33(1):1-5,15,6.基金项目
国家自然科学基金(61475182 （）
81522024 （）
81427804) （）
广东省科技计划(2014B050505013) （2014B050505013）
深圳市基础研究计划(YJ20150521144321005 （）
JCYJ20150401145529037 （）
JCYJ20150731154850923 （）
JCYJ20160608214524052 （）
JCYJ20160531175040976 （）
JCYJ20170413153129570) （）
中科院优秀青年基金(2017048). （2017048）
