中国医疗设备2018，Vol.33Issue(1)：6-10,15,6.DOI:10.3969/j.issn.1674-1633.2018.01.002
梯度匀场参数优化及其在非人灵长类动物磁共振成像中的应用
Optimization of the Gradient Shimming Protocol and Its Application in Magnetic Resonance Imaging of Non-Human Primates' Brain Function
摘要
Abstract
The study on non-human primates' brain function network and its advanced cognitive function by utilizing magnetic resonance imaging (MRI) stands for an important developing trend of neuroscience. However, the geometrical features of non-human primates' skull will lead to an inhomogeneity in the local magnetic field, and jeopardize the quality of MRI severely. In this study, a field map-based gradient shimming sequence protocol was optimized (including improval of the spatial resolution of the field map and shrink the adjustment volume) and then compared with the traditional shimming technique on a 3.0 T clinical MRI scanner. A MRI phantom with a geometrical structure inside and a non-human primate (one adult macaque) were scanned. Qualitative estimation was carried out by the phase difference imaging based on the gradient echo and the quantitative evaluation was performed by the full width at half maximum height (FWHM) of the spectrum. Results showed that the FWHM of the free-induction decay (FID) in the phantom's adjustment volume reduce by more than 34% (P<0.001) and the uniformity of the magnetic field could be improved profoundly, by using the optimized shimming protocol. Meanwhile, the geometrical distortion of the imaging of the non-human primate in vivo experiment had been significantly improved by the new method.Therefore,the optimized shimming protocol can effectively enhance the quality of shimming and diminish the imaging geometry distortion derived from the inhomogeneous magnetic field, which in turn meets the requirements of MRI of non-human primates' brain function.关键词
梯度匀场/非人灵长类动物/功能磁共振成像/图像质量Key words
gradient shimming/non-human primate/functional magnetic resonance imaging/imaging guality分类
医药卫生引用本文复制引用
俞文文,王征,聂生东..梯度匀场参数优化及其在非人灵长类动物磁共振成像中的应用[J].中国医疗设备,2018,33(1):6-10,15,6.基金项目
国家自然科学基金(60972122) （60972122）
上海市自然科学基金(14ZR1427900). （14ZR1427900）
