中国当代儿科杂志2018，Vol.20Issue(1)：72-76,5.DOI:10.7499/j.issn.1008-8830.2018.01.015
TRPC6与肾脏疾病关系的研究进展
Research advances in the association between transient receptor potential cation channel 6 and kidney disease
摘要
Abstract
Transient receptor potential cation channel 6 (TRPC6) is a member of the transient receptor superfamily encoded by the TRPC6 gene and is widely expressed in tissues and organs of the human body, especially in the glomerular podocytes. TRPC6 interacts with various slit diaphragm (SD) proteins including podocin, nephrin, ACTN4, and CD2AP to maintain the normal structure and function of glomerular podocytes. Foot process fusion caused by podocyte damage due to various factors is the most important morphological change in kidney disease. This article reviews the biological function of TRPC6 and its effect on kidney disease.关键词
TRPC6/肾小球足细胞/肾脏疾病Key words
Transient receptor potential cation channel 6/Podocyte/Kidney disease引用本文复制引用
曹珊..TRPC6与肾脏疾病关系的研究进展[J].中国当代儿科杂志,2018,20(1):72-76,5.基金项目
国家自然科学基金项目(81460143). （81460143）
