中国临床药理学与治疗学2017，Vol.22Issue(10)：1112-1116,5.
依折麦布与考来替泊交替给药对于高脂血症大鼠脂代谢的调节作用
Alternate dosing of ezetimibe and colestipol on regulating lipid metabolism in hyperlipidemia rats
摘要
Abstract
AIM:To explore alternate dosing of ezetimibe and colestipol on regulating for lipid metabolism in hyperlipidemia rats.METHODS:Fifty rats of clean grade,half male and female were modeling through feeding high fat diet;the rats were randomly divided into normal group,model group,and experimental groups (including ezetimibe group,colestipol group,ezetimibe + colestipol group);experimental groups received gavage administration,while the normal group and model group were given normal saline for 8 weeks;TG,TC,HDL-C,LDL-C and ACC,FAS,HMGR,CPT-Ⅰ expression of mRNA in serum were thereafter detected.RESULTS:The levels of TC,TG,LDL-C and AAC,FAS,HMGR mRNA in serum were decreased,and levels of ezetimibe + colestipol group were significantly lower than those of single drug group (P ＜ 0.05).CONCLUSION:Alternate dosing of ezetimibe and colestipol was better than single medication in regulating lipid metabolism in hyperlipidemia rats,but the effect on human body still needs further clinical validation.关键词
依折麦布/考来替泊/高脂血症Key words
ezetimibe/colestipol/hyperlipidemia分类
医药卫生引用本文复制引用
杨毅,官俏兵,郭丽,李文燕,张慧,韩晨阳..依折麦布与考来替泊交替给药对于高脂血症大鼠脂代谢的调节作用[J].中国临床药理学与治疗学,2017,22(10):1112-1116,5.基金项目
浙江省科技厅项目(2017C37174) （2017C37174）
