中国临床药理学与治疗学2017，Vol.22Issue(10)：1162-1166,5.
经皮雌二醇凝胶与口服戊酸雌二醇片在冻融胚胎移植中的临床应用疗效比较
A comparison of clinical applications of transdermal estradiol and estradiol valerate on endometrial receptivity in frozen-thawed embryo transfer cycles
金聪聪 1王佩玉 1林佳 1周玮 1杨海燕1
作者信息
- 1. 温州医科大学附属第一医院生殖医学中心,温州325000,浙江
- 折叠
摘要
Abstract
AIM:To compare the clinical outcome of two endometrial preparation protocols (oral estradiol vs 17 β-estradiol transdermal gel) in frozenthawed blastocyst transfer.METHODS:One hundred and twenty FET cycles were analyzed from July 2016 to December 2016.All cases were divided into two groups:group A (n =60) received transdermal gel application for 60 cycles,while group B received (n =60) oral estradiol valerate for 60 cycles.Patient's age,basic endocrine,endometrial thickness on the day of progesterone initiation,high quality embryo rate,mean number of embryo transferred per patient,implantation rate,clinical pregnancy rate,early abortion rate and ectopic pregnancy rate were compared between the two groups.RESULTS:Clinical pregnancy rate and implantation rate of group A (63.63％ and 52.72％) were higher than those of group B(61.11％ and 46.29％,respectively),but there were no statistically significant difference (P ＞0.05).The total amount of estradiol used[(102.6.8±34.10 vs 85.52±17.18) mg] in group A was significantly higher than that in group B (P ＜ 0.05),and the total duration of estradiol used[(16.80 ± 4.02) vs (12.64±2.52) d] in group A was significantly higher than that in group B (P ＜ 0.05).No significant differences of other indicators were observed between the two groups.CONCLUSION:In frozen-thawed embryo transfer,estradiol transdermal gel endometrial preparation protocol can obtain the similar pregnancy rate compared with taking estradiol valerate.Estradiol transdermal gel can be used as an effective clinical method for patients with abnormal liver function and hyperlipidaemia.Yet,the dosage and span time increased,estradiol transdermal gel as a regular recommendation still need further discussion.关键词
雌二醇/冻融胚胎移植/经皮/子宫内膜准备/妊娠结局Key words
estradiol/frozen-thawed embryo transfer/transdermal/endometrial preparation/pregnancy outcome分类
医药卫生引用本文复制引用
金聪聪,王佩玉,林佳,周玮,杨海燕..经皮雌二醇凝胶与口服戊酸雌二醇片在冻融胚胎移植中的临床应用疗效比较[J].中国临床药理学与治疗学,2017,22(10):1162-1166,5.
