中国临床药理学与治疗学2017，Vol.22Issue(10)：1180-1188,9.
法尼酯衍生物X受体基因多态性与代谢性疾病的相关性
Farnesoid X receptor gene polymorphisms and metabolic disease
摘要
Abstract
Farnesoid X receptor (FXR)is a ligand-activated transcription factor that maintains homeostasis.In the nucleus,FXR forms a heterodimer with RXR and binds to inverted repeat elements separated by one nucleotide (IR-1) to regulate the expression of target genes.Highly expressed in the human liver,intestine,kidneys and adrenals,FXR is an important regulator of bile acid,lipid and glucose metabolism.This makes FXR a potential therapeutic target in metabolic disease.What's more,FXR SNPs (single-nucleotide polymorphisms) are proved to be associated with cholelithiasis,glucose homeostasis,intrahepatic cholestasis and obesity.This review focuses on the metabolic pathway and the gene polymorphism of FXR,which can bring the results of early identification and prevention of some metabolic diseases.关键词
法尼酯X受体/基因多态性/代谢性疾病Key words
farnesoid X receptor/gene polymorphism/metabolic disease分类
医药卫生引用本文复制引用
徐千,李玲,魏婉慧,赵慧佳,时玉颖,乐江,王彦峰,叶啟发..法尼酯衍生物X受体基因多态性与代谢性疾病的相关性[J].中国临床药理学与治疗学,2017,22(10):1180-1188,9.基金项目
湖北省自然科学基金创新群体(2015CFA018) （2015CFA018）
湖北省卫计委药护技和管理专项(WJ2017H0024) （WJ2017H0024）
武汉大学中南医院药护技和管理专项(xcpy20160062) （xcpy20160062）
