中国临床药理学与治疗学2017，Vol.22Issue(10)：1189-1194,6.
环状RNA的功能及在结直肠癌中的研究进展
Circular RNA: function and role in colorectal cancer
摘要
Abstract
Colorectal cancer (CRC) is a common human digestive system malignant tumor,and its morbidity and mortality are in the third place among different diseases.Many factors including age,life style,obesity,and smoking are involved in the morbidity of CRC.Recent studies have demonstrated the abnormal expressions of non-coding RNAs,including circular RNA,participate in the development and progression of CRC.CircRNAs are a novel type of endogenous long noncoding RNAs,unlike the better known linear RNA,forms a covalently closed continuous loop.Recent studies indicate that circRNAs can function as sponges of miRNA and regulators of splicing and transcription.CircRNAs can also modulate protein-protein interaction and affect the maturation of ribosomal.Emerging evidence indicates that circRNAs play a vital role in controlling the proliferation,metastasis and invasion of tumor cells.This review focuses on the function of circRNAs and discusses its role in colorectal cancer.关键词
结直肠癌/环状RNAKey words
colorectal cancer/circRNA分类
医药卫生引用本文复制引用
彭向东,方伟进,何阳,郭韧..环状RNA的功能及在结直肠癌中的研究进展[J].中国临床药理学与治疗学,2017,22(10):1189-1194,6.基金项目
湖南省卫生计生委科研项目(B2017029)临床药学国家临床重点专科建设项目 （B2017029）
