中国临床药理学与治疗学2017，Vol.22Issue(11)：1227-1231,5.
微乳载药体系对α-倒捻子素抗滑膜细胞增殖的增效作用研究
Microemulsion as the drug delivery system improves inhibitory effects of α-mangostin on synovium
摘要
Abstract
AIM:α-Mangostin (MG) is a xanthone with antirheumatic effect.To improve the pharmacokinetic performance,we prepared MG loaded microemulsion (MG-ME).This study was designed to evaluate its potential improvements to therapeutic efficacy.METHODS:Intakes of MG by cells were determined by HPLC.Inhibition on proliferation of cells was assessed by MTT method.Western blot was employed to investigate modulation of MG on transduction pathways.The therapeutic efficacy of MG was evaluated based on the effects on adjuvant induced arthritis in rats.RESULTS:Microemulsion improved the intakes of MG in human fibroblast-like synoviocyte rheumatoid arthritis (HFLS-RA) cells,which resulted in the enhanced inhibition on proliferation of cells and modulations on p38 and NF-κB signalings.Also,this delivery system was found augmenting the protection on joints in vivo.CONCLUSION:Microemulsion improved the intakes of MG and the sensitivity of drug stimulation in HFLS-RA cells.It enhances the dru efficacy in vivo and is a promising delivery system for antirheumatic agents.关键词
α-倒捻子素/HFLS-RA细胞/滑膜/类风湿性关节炎/微乳Key words
α-Mangostin/HFLS-RA cell/synovium/rheumatoid arthritis/microemulsion分类
医药卫生引用本文复制引用
郭辉霞,陶梦情,左坚,汪魏平..微乳载药体系对α-倒捻子素抗滑膜细胞增殖的增效作用研究[J].中国临床药理学与治疗学,2017,22(11):1227-1231,5.基金项目
安徽省卫生计生委中医药科研课题项目(2016zy37) （2016zy37）
