中国临床药理学与治疗学2017，Vol.22Issue(11)：1232-1236,5.
龙血通络胶囊对脑缺血性损伤保护作用的实验研究
Protective effects of Longxuetongluo capsule on cerebral ischemia injury in rats
摘要
Abstract
AIM:To investigate the protective effects of Longxuetongluo capsule on cerebral ischemia injury in rats.METHODS:The focal cerebral ischemia model was established to observe the extent of the pathological alteration and the focal cerebral ischemia reperfusion model was established to observe the change of behavior in rats.Meanwhile,the influence of Longxuetongluo capsule on the levels of Glutathione peroxidase (GSH-Px),superoxide dismutase (SOD),lactate dehydrogenase (LDH),Malondialdehyde (MDA),NO and Induced nitric oxide synthase (iNOS) were investigated.RESULTS:Compared with model group,Longxuetongluo capsule of 0.66,0.33g/kg ameliorated neurologic deficits score and reduced the water content of brain tissue.In addition,Longxuetongluo capsule of 0.66 g/kg,0.33g/kg can remarkly increased the levels of GSH-Px,SOD,LDH and decreased the activity of iNOS and the contents of NO and MDA.CONCLUSION:Longxuetongluo capsule has profective effects on cerebral ischemia injury and the mechanism maybe related to the resistance of free radical damage and the inhibiton of iNOS.关键词
龙血通络胶囊/脑缺血/SOD/NO/iNOSKey words
Longxuetongluo capsule/cerebral ischemia/SOD/NO/iNOS分类
医药卫生引用本文复制引用
李睿,罗胜勇..龙血通络胶囊对脑缺血性损伤保护作用的实验研究[J].中国临床药理学与治疗学,2017,22(11):1232-1236,5.基金项目
安徽省自然科学基金(1608085MH161) （1608085MH161）
