中国临床药理学杂志2017，Vol.33Issue(21)：2095-2097,3.DOI:10.13699/j.cnki.1001-6821.2017.21.001
乌司他丁注射剂联合血液净化术治疗重症感染性休克患者的临床研究
Clinical trial of ulinastatin injection combined with blood purification in the treatment of patients with severe septicon shock severe
摘要
Abstract
Objective To observe the effect of ulinastatin injection combined with blood purification on inflammatory mediators and oxygenation index in patients with severe septic shock.Methods A total of 100 patients with severe septic shock were randomly divided into control group (n =50) and treatment group (n =50).Control group was treated with regular treatment.Treatment group was given ulinastatin 2.0 × 105 U + 0.9％ NaCl 20 mL + blood purification for 24 h on the basis of control group.The treatment was continued for 3 d.The clinical efficacy,tumor necrosis factor-α,interleukin-8,interleukin-6,oxygenation index (PaO2/FiO2),and the incidence of adverse drug reactions were observed in two groups.Results After treatment,total effective rates in treatment group and control group were 90.00％ (45 cases/50 cases),52.00％ (26 cases/50 cases),with significant difference (P ＜ 0.05).After treatment,the levels of tumor necrosis factor-αt,interleukin-8 and interleukin-6 in treatment group were (8.39 ± 3.14),(4.21 ± 1.14),(4.95 ± 1.77) μg · L-1,had significant difference with those in control group,which were (17.28 ±2.91),(9.07 ± 1.04),(10.99± 1.32) μg· L-1 (P ＜0.05).After 1,12,24,72 h treatment,the PaO2/FiO2 in treatment group were 141.21 ± 16.92,187.82 ± 21.51,203.12 ± 26.30,284.21 ± 45.12,had significant difference with those in control group,which were 135.31 ± 19.23,149.30 ±20.60,178.72 ±29.21,199.60 ±40.52(P ＜0.05).There was no adverse drug reactions in two groups during the treatment.Conclusion Ulinastatin combined with blood purification has significant effect in patients with severe septic shock,can significantly reduce inflammatory mediators and improved oxygenation index.关键词
鸟司他丁/血液净化术/感染性休克/炎症介质/氧合指数Key words
ulinastatin/continuous blood purification/septic shock/oxygenation index分类
医药卫生引用本文复制引用
陈东娇,麦叶..乌司他丁注射剂联合血液净化术治疗重症感染性休克患者的临床研究[J].中国临床药理学杂志,2017,33(21):2095-2097,3.基金项目
海南省自然科学基金资助项目(814321) （814321）
