中国临床药理学杂志2017，Vol.33Issue(21)：2135-2138,4.DOI:10.13699/j.cnki.1001-6821.2017.21.013
基于变异系数权重的模糊物元模型评价当归不同提取部位补血的效果
Evaluating the effect of blood nourishing of Angelica's different extracted parts with Fuzzy Matter-element model based on variation coefficient weight
摘要
Abstract
Objective To select the effective parts of blood nourishing and to investigate the utilization of fuzzy matter-element model in evaluating the effect of blood nourishing of Angelica's different extracted parts.Methods KM mice half males and half females were randomly divided into 10 groups,including blank control group,model group (blood-deficiency),positive control group (Complex Prescription Glue Mucilage:0.02 mL· g-1),experimental group consisted by 7 different extracted parts of Angelica (3.4 g kg-1 Angelica herbs) Acetylphenyhydrazine (APH) and cyclophosphamide (CTX) were used to copy the blood-deficiency model mice by administration APH at the second day (20 mg · kg-1) and the fifth day (40 mg · kg-1) respectively,since the fifth day,ip CTX 40 mg · kg-1 everyday,once a day for four days.Periphera hemogram and organ index,including thymus index (TI),spleen index (SI),were detected at the 10th day.Then using Fuzzy Matter-element model on variation coefficient weight.Results The TI,SI,red blood cell (RBC),platelet count(PLT),hematokrit (HCT),hemoglobin (HGB),white blood cell (WBC) were (7.70 ± 1.81) × 10-2,(56.90 ± 12.23) × 10-2,8.44 ± 1.59,1453.10 ± 102.50,56.54 ± 6.69,170.00 ± 26.39,2.10 ± 0.49,respectively in model group.The 70％ ethanol impregnation part (part 2) for TI,SI,RBC,PLT,HCT,HGB,WBC were 0.10 ± 2.66 ×10-2,(33.83 ±8.97) × 10-2,11.94 ±2.07,1749.60 ±211.50,55.53 ±9.42,55.53 ±9.42,2.60 ± 0.47,respectively.The part 2 can increase TI,RBC,PLT,HCT,WBC and reduce SI,HGB.Compared with model group,the difference was statistically significant in SI,RBC,PLT,HCT,WBC (P ＜ 0.05 or P ＜ 0.001).There were no significant differences between part 1 and part 2 (P ＞ 0.05).Combining with the result of the value of Euclid approach degree,in part 1-7,the maximum is 0.50 (part 2),is greater than 0.40 (part 1).Conclusion The 70％ alcohol impregnation part is the effective part of blood nourishing.The method and model can be used to objectively evaluate the comprehensive effect of blood nourishing of Angelica's different extracted parts.关键词
当归不同提取部位/补血/模糊物元模型/变异系数权重Key words
Angelica's different extracted parts/blood nourishing/fuzzy matter-element model/variation coefficient weight分类
医药卫生引用本文复制引用
朱顺娟,张启立,吴国泰,夏鹏飞,李娜,栗铭笛,赵磊..基于变异系数权重的模糊物元模型评价当归不同提取部位补血的效果[J].中国临床药理学杂志,2017,33(21):2135-2138,4.基金项目
国家自然科学基金资助项目(81660577) （81660577）
甘肃省自然科学基金资助项目(148RJZA064) （148RJZA064）
甘肃省中医药管理局科研基金资助项目(GZK-2014-77) （GZK-2014-77）
甘肃省发展和改革委员会陇药产业发展专项基金资助项目(甘财经(2015) 164号) （甘财经(2015）
甘肃中医药大学校企合作基金资助项目(2015-1) （2015-1）
甘肃中医学院中青年科研基金资助项目(ZQ2014-2) （ZQ2014-2）
