中国临床药理学杂志2017，Vol.33Issue(21)：2206-2208,3.DOI:10.13699/j.cnki.1001-6821.2017.21.031
溶酶体决定荷脂细胞的自噬流研究进展
Progress in lysosome: key regulator of autophagy in lipid loaded cells
摘要
Abstract
The capacity of reverse cholesterol transport (RCT) of lipid loaded cells is critical of atherosclerosis(AS) development.Autophagy is an important regulatory mechanism promoting RCT.But the exact effects of autophagy activation or inhibition on RCT remain unclear in AS.So in this review we suggest that partly inhibition of autophagy or induction of lysosomal biogenesis improves the autophagy capacity of lipid loaded cells.关键词
荷脂细胞/动脉粥样硬化/自噬/溶酶体/胆固醇逆转运Key words
lipid loaded cell/atherosclerosis/autophagy/lysosome/reverse cholesterol transport分类
医药卫生引用本文复制引用
敖宝学,朱能,刘潺,谢志忠,廖端芳,覃丽..溶酶体决定荷脂细胞的自噬流研究进展[J].中国临床药理学杂志,2017,33(21):2206-2208,3.基金项目
国家自然科学基金资助项目(81270359,81670268,31371161) （81270359,81670268,31371161）
湖南省教育厅重点基金资助项目(15A138) （15A138）
湖南省中医药管理局重点基金资助项目(201614) （201614）
