中国临床药理学杂志2017，Vol.33Issue(22)：2215-2218,4.DOI:10.13699/j.cnki.1001-6821.2017.22.001
硫酸特布他林雾化液和布地奈德混悬液联合多索茶碱治疗变异性哮喘患儿的临床研究
Clinical trial of terbutaline sulfate atomization and budesonide suspension combined with doxophylline in the treatment of children with variant asthma
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of the two different ways inhalated terbutaline sulfate and budesonide combined with doxofylline in the treatment of children with variant asthma.Methods A total of 78 children with variant asthma were randomly divided into treatment group and control group,with 39 cases in each group.Patients in both groups were given conventional treatment and symptomatic treatment.Control group was used ultrasonic atomization inhalation,and treatment group was used air compression pump atomization.Two groups were treated with terbutaline sulfate atomization 2 mL + budesonide suspension 2 mL + 0.9％ NaCl 20 mL,twice a day.All patietns were given doxofylline 5 mg· kg-1 + 5％ glucose solution 50 mL,intravenous infusion,once a day.All patients were treated for 5 d.The clinical efficacy,peripheral blood eosinophilic granulocyte (EOS),eosinophilic granulocyte cation protein (ECP),immunoglobulin E (IgE),interleukin-4 (IL-4) and adverse drug reactions were compared between the two groups.Results The total effective rates in treatment group and control group were 92.31％ (36 cases/39 eases),74.36％ (29 cases/39 cases),with significant difference(P ＜0.05).After treatment,peripheral blood eosinophilic granulocyte,immunoglobulin E,interleukin-4 in control group were (0.79 ±0.10) × 109/L,(176.49 ±20.11) U · mL-1,(80.92 ±9.78) ng · mL-1,had significant difference with those in treatment group,which were (0.54 ±0.07) × 109/L,(107.49 ± 14.44) U · mL-1,(50.98 ±6.44) ng· mL-1 (P ＜0.05).The forced expiratory volume in 1 s,forced vital capacity,forced expiratory volume in 1 s/forced vital capacity in control group were (0.64 ±0.10)L,(2.38 ±0.29)L,80.39 ± 8.98,had significant difference with those in treatment group,which were (0.70 ±0.12) L,(3.38 ±0.37)L,90.88 ± 10.02 (P ＜0.05).The adverse drug reactions in control group and treatment group were gastrointestinal discomfort and rash,total incidence rates of control group and treatment group were 5.13％ (2 cases/39 cases),7.69％ (3 cases/39 cases),with no significant difference (P ＞ 0.05).Conclusion The clinical efficacy of doxofylline combined with air compressor pump atomizing inhalation in the treatment of children with variant asthma is significant higher than combined with ultrasonic atomizing inhalation,with high safety.关键词
硫酸特布他林/布地奈德/多索茶碱/雾化方式/变异性哮喘患儿Key words
terbutaline sulfate/budesonide/doxofylline/atomization/children with variant asthma分类
医药卫生引用本文复制引用
张建丽..硫酸特布他林雾化液和布地奈德混悬液联合多索茶碱治疗变异性哮喘患儿的临床研究[J].中国临床药理学杂志,2017,33(22):2215-2218,4.基金项目
浙江省卫生适宜技术成果转化计划基金资助项目(2011ZHB012) （2011ZHB012）
