中国临床药理学杂志2017，Vol.33Issue(22)：2219-2221,3.DOI:10.13699/j.cnki.1001-6821.2017.22.002
乌司他丁注射液对缺血性脑卒中患者介入术后神经保护功能及S-100β蛋白表达影响
Effects of ulinastatin injection on neural function and the expression of S-100β protein in ischemic stroke patients who underwent interventional therapy
摘要
Abstract
Objective To analysis the effects of ulinastatin injection on neural function and the expression of S-100β protein apply to ischemic stroke patients who underwent interventional therapy.Methods A total of 92 patients with ischemic stroke were randomly divided into control group (n =46) and treatment group (n =46).The control group received conventional treatment (oral administration of atorvastatin statin 20 mg,aspirin100 mg and clopidogrel 75 mg,qd) consecutively for 30 d.On the basis of the control group,the treatment group received intravous ulinastatin 1 × 105 U (diluted in 0.9％ NaCl 250 mL) bid for 7 d (the last 7 days of the treatment).The clinical efficacy,S-100β protein,National institutes of health stroke scale (NIHSS) before and after treatment and the adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates of the treatment group and control group were 95.65％ (44 cases/46 cases) and 78.26％ (36 cases/46 cases),with statistically significant difference (P ＜ 0.05).After treatment,the S-100 β protein of the treatment group and the control group respectively were (1.91 ±0.24) and (2.31 ±0.29) μg · L-1,NIHSS respectively were 9.24 ± 1.11 and 11.23 ± 1.42,and the difference was statistically significant (P ＜ 0.05).The adverse drug reaction in the treatment group was restenosis (1 case),while that of the control group were restenosis (2 cases) and cerebral ischemia (4 cases).The incidences of adverse drug reactions of the treatment group and the control group were 2.17％ (1 case/46 cases) and 13.04％ (6 cases/46 cases),with statistically significant difference (P ＜ 0.05).Conclusion Ulinastatin exerted protective effect on neural system of ischemic stroke patients who underwent interventional therapy can protect nerve function by suppressing the expression of S-100β protein.关键词
缺血性脑卒中/介入术/乌司他丁/神经功能保护/S-100β蛋白Key words
ischemic stroke/intervention/ulinastatin/neurologic protection/S-100β protein分类
医药卫生引用本文复制引用
姚绍鑫,王健..乌司他丁注射液对缺血性脑卒中患者介入术后神经保护功能及S-100β蛋白表达影响[J].中国临床药理学杂志,2017,33(22):2219-2221,3.基金项目
河北省科技计划基金资助项目(15277791D) （15277791D）
