中国临床药理学杂志2017，Vol.33Issue(22)：2222-2225,4.DOI:10.13699/j.cnki.1001-6821.2017.22.003
辛伐他汀片联合硫酸氢氯吡格雷片治疗不稳定型心绞痛的临床研究
Clinical trial of simvastatin tablet combined with clopidogrel bisulfate tablet in the treatment of unstable angina pectoris
摘要
Abstract
Objective To observe the clinical efficacy and safety profile of simvastatin combined with clopidogrel bisulfate in the treatment of unstable angina pectoris (UAP).Methods A total of 107 UAP patients were randomly divided into treatment group (n =53) and control group (n =54).Both groups were given conventional treatment.The control group received oral administration of simvastatin 40 mg once daily,while the treatment group received oral administration of clopidogrel bisulfate (initiated with a single 300 mg loading dose and then continued at 75 mg once a day) on the basis of control group.The total effective rate,hemorheology,the level of Fractalkine,monocyte chemoattractant protein-1 (MCP-1),quality of life scores (QOL) and adverse drug reactions were compared between the two groups after 6-month treatment.Results The total effective rates of the treatment group and the control group were 90.57％ (48 cases/53 cases) and 74.07％ (40 cases/54 cases) respectively,the difference was statistically significant (P ＜ 0.05).After treatment,the fibrinogen level in the treatment group and the control group were (3.96 ± 0.63),(4.52 ± 0.64) g · L-1,the plasma viscosity were (1.66 ±0.21),(1.81 ± 0.23) mPa · s,the erythrocyte aggregation indices were 2.89 ± 0.41,3.84 ± 0.39,the erythrocyte sedimentation rates were respectively (23.13 ± 7.35),(25.05 ± 7.01)mm · h-1,the platelet aggregation rates were respectively (38.79 ± 2.87) ％,(42.79 ± 3.17) ％,the Fractalkine were (34.74 ± 5.82),(40.42 ± 6.13)ng · L-1,the MCP-1 were (43.16 ±5.61),(48.89 ±6.29) ng· L-1,respectively,and the differences between the treatment group and the control group were statistically significant (P ＜0.05).The drug adverse reactions of the two groups were elevated liver transaminase,gastrointestinal reaction and skin purpura,the adverse drug reactions in the treatment group and the control group were 9.43％ (5 cases/53 cases) and 9.25％ (5 cases/54 cases),respectively,with no statistically significant difference (P ＞0.05).Conclusion Simvastatin combined with clopidogrel bisulfate could effectively improve the hemorheology and reduce the level of Fractalkine and MCP-1 in UAP patients,with satisfying safety profile.关键词
辛伐他汀/硫酸氢氯吡格雷/不稳定型心绞痛/血流动力学Key words
simvastatin/clopidogrel bisulfate/unstable angina pectoris/hemorheology分类
医药卫生引用本文复制引用
林玲,何五建,陆士奇,黄芳..辛伐他汀片联合硫酸氢氯吡格雷片治疗不稳定型心绞痛的临床研究[J].中国临床药理学杂志,2017,33(22):2222-2225,4.基金项目
苏州市科教兴卫青年课题基金资助项目(KJXW2014001) （KJXW2014001）
