中国临床药理学杂志2017，Vol.33Issue(22)：2230-2232,3.DOI:10.13699/j.cnki.1001-6821.2017.22.005
新疆维吾尔族和汉族肺结核患者白细胞介素-10及人肿瘤坏死因子-α表达水平的比较研究
Comparative study on the interleukin-10 and tumor necrosis factor-α level in the pulmonary tuberculosis patients of Uygur and Han population in Xinjiang
摘要
Abstract
Objective To investigate the levels of human tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) in the serum of Han and Uygur tuberculosis (TB) patients,and to analyze the relationship between sexes.Methods A total of 132 Han patients and 122 Uygur patients with TB were enrolled in this study.The levels of TNF-α and IL-10 in serum were measured by commercially available enzyme linked immune-sorbent assay (ELISA).Results The serum TNF-α of the Han and Uygur patients were (21.72 ±7.18),(29.86 ±8.61)pg · mL-1;IL-10 levels in the Han and Uygur patients were (34.90±11.18) pg·mL-1,(41.65±18.11) pg· mL-1.There were significant differences between the Han and the Uygur patients (P ＜0.05).The concentration of serum IL-10 in male and female patients were (44.93 ± 18.56),(38.95 ± 13.13) pg · mL-1,and significant difference was found between the two genders (P ＜ 0.05) in Uygur,while there was no significant difference in TNF-α.Moreover,no significant difference was found in IL-10 and TNF-α between the two genders in Han patients.Conclusion There were significant differences in the serum TNF-α and IL-10 between the Han and the Uygur patients,while significant difference was also found in the serum TNF-α between the two genders in Han and Uygur TB patients.关键词
汉族/维吾尔族/肺结核/肿瘤坏死因子-α/白细胞介素-10Key words
Han population/Uygur population/pulmonary tuberculosis/tumor necrosis factor-α/interleukin-10分类
医药卫生引用本文复制引用
王晓义,谢松松,程丽,李国昌,王新春..新疆维吾尔族和汉族肺结核患者白细胞介素-10及人肿瘤坏死因子-α表达水平的比较研究[J].中国临床药理学杂志,2017,33(22):2230-2232,3.基金项目
国家自然科学基金资助项目(81260079) （81260079）
