中国临床药理学杂志2017，Vol.33Issue(22)：2233-2235,2238,4.DOI:10.13699/j.cnki.1001-6821.2017.22.006
噻托溴铵粉吸入剂联合茶碱缓释片治疗稳定期慢性阻塞性肺疾病的临床研究
Clinical trial of tiotropium bromide powder inhalation combined with theophylline sustained-release tablets in the treatment of chronic obstructive pulmonary disease in stable phase
摘要
Abstract
Objective To observe the clinical efficacy and safety of the tiotropium bromide powder inhalation combined with theophylline sustained-release tablets in the treatment of chronic obstructive pulmonary disease(COPD) in stable phase.Methods Forty patients of COPD in stable phase were randomly divided into control group and treatment group with 20 cases per group.Control group was given theophylline sustained-release tablets 0.2 g,bid,oral.Treatment group was given tiotropium bromide powder inhalation 18 μg,qd,Inhalation therapy.The clinical efficacy,mean blood oxygen saturation at nigh (MSaO2),lowest blood oxygen saturation (LSaO2),the ratio on the blood oxygen saturation ＜ 90％ of the total amount of sleep time (T90) and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in the treatment and control groups were 95.00％ (19 cases/20 cases)and 65.00％ (13 cases/20 cases) with statistically significant difference (P ＜ 0.05).After treatment,the main indexes in the treatment and control groups were compared:MSaO2 were (93.72 ± 3.44) ％ and (86.42 ± 4.11) ％,LSaO2 were (92.53 ±5.64)％ and(86.94 ±6.23)％,T90 were(28.14 ±6.31)％ and(31.22 ±7.81)％,the differences were statistically significant(all P ＜0.05).The adverse drug reactions in treatment group were based on dry mouth,which in control group were based on mild stomach discomfort.The incidences of adverse drug reaction in the treatment and control groups were 10.00％ and 5.00％ without significant difference(P ＞ 0.05).Conclusion Tiotropium bromide powder inhalation combined with theophylline sustained-release tablet has a definitive clinical efficacy and safety in the treatment of COPD in stable phase,which can improve the respiratory function.关键词
茶碱缓释片/噻托溴铵粉吸入剂/慢性阻塞性肺疾病/安全性Key words
theophylline sustained-release tablet/tiotropium bromide powder inhalation/chronic obstructive pulmonary disease/safety分类
医药卫生引用本文复制引用
姜锋,郑洪飞,柳雅军,杨林瀛,庞桂芬,李金玲,张庆..噻托溴铵粉吸入剂联合茶碱缓释片治疗稳定期慢性阻塞性肺疾病的临床研究[J].中国临床药理学杂志,2017,33(22):2233-2235,2238,4.基金项目
承德市科学技术研究与发展计划基金资助项目(20157040) （20157040）
