中国临床药理学杂志2017，Vol.33Issue(22)：2236-2238,3.DOI:10.13699/j.cnki.1001-6821.2017.22.007
替吉奥胶囊联合同步放疗治疗晚期胃癌的临床研究
Clinical trial of tegafur gimeracil and oteracil potassium capsules combined with radiotherapy in the treatment of advanced gastric cancer
穆克代斯·伊力亚斯 1巴尔夏古丽·扎比胡拉 1伊斯刊达尔·阿布力米提1
作者信息
- 1. 新疆医科大学附属肿瘤医院胸腹放疗科,乌鲁木齐830011
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy and safety of tegafur gimeracil and oteracil potassium capsules combined with radiotherapy in the treatment of advanced gastric cancer.Methods A total of 92 patients with advanced gastric cancer were randomly divided into control group and treatment group with 46 cases per group.Control group received radiotherapy,five times a week.Treatment group was given 40 mg· m-2 tegafur gimeracil and oteracil potassium capsules,every morning and night,orally fro 14 day and stop for 7 days,on the basis of control group.Two groups were treated for 2 cycles with 21 d per cycle.The clinical efficacy and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in the treatment and control groups were 67.39％ (31 cases/46 cases) and 45.65％ (21 cases/46 cases),the 1-year survival rates in the treatment and control groups were 69.57％ (32 cases/46 cases) and 45.65％ (21 cases/46 cases),the differences were statistically significant (all P ＜0.05).In the treatment and control groups,the incidences of nausea and vomiting with grade Ⅲ-Ⅳ were 2.17％ and 15.22％,the incidences of increasing transaminase with grade Ⅰ-Ⅱ were 17.39％ and 36.96％,the incidences of leukopenia with grade Ⅲ-Ⅳ were 10.87％ and 39.13％,the differences were statistically significant (all P ＜ 0.05).Conclusion Tegafur gimeracil and oteracil potassium capsules combined with radiotherapy have a definitive clinical efficacy and safety in the treatment of advanced gastric cancer.关键词
替吉奥胶囊/放疗/胃癌/安全性Key words
tegafur gimeracil and oteracil potassium capsule/radiotherapy/gastric cancer/safety分类
医药卫生引用本文复制引用
穆克代斯·伊力亚斯,巴尔夏古丽·扎比胡拉,伊斯刊达尔·阿布力米提..替吉奥胶囊联合同步放疗治疗晚期胃癌的临床研究[J].中国临床药理学杂志,2017,33(22):2236-2238,3.
