中国临床药理学杂志2017，Vol.33Issue(22)：2239-2242,4.DOI:10.13699/j.cnki.1001-6821.2017.22.008
大剂量甲氨蝶呤治疗淋巴系统肿瘤的药物不良反应影响因素分析
Analysis of influencing factors on the drugs adverse reactions of high dose methotrexate in the treatment of patients with lymphatic tumors
摘要
Abstract
Objective To investigate the influencing factors of adverse drug reactions after high-dose methotrexate (HD-MTX) chemotherapy,and to provide evidence for personalized medicine of methotrexate.Methods Clinical cases of 147 patients with lymphatic cancer were collected from June 2014 to December 2016 in hematology center and pediatric center of the First Affiliated Hospital of Xinjiang Medical University,the information of patients before and after chemotherapy were recorded,and then analyzed the influencing factors of adverse drug reactions by method of single factor.Results Factors that affected adverse drug reactions included ethnic,age,the number of courses,combined with chemotherapy,the number of platelet (PLT),alanine aminotransferase (ALT) and aspartate transaminase (AST) before chemotherapy,body mass index (BMI),body surface area and dosage of methotrexate (P ＜ 0.05).The incidence of myelosuppression:Patients with abnormal PLT before chemotherapy was higher than normal ones,the large body surface area were higher than small body surface area.The incidence of hepatic injury:child patients were higher than adults,patients with single HD -MTX chemotherapy were higher than combined chemotherapy,patients who received chemotherapy more than 3 courses were higher than those less than 2 courses,the abnormal liver function before chemotherapy were higher than normal the ones,the small body surface area were higher than the large body surface area,the high dose MTX were higher than low dose MTX.The incidence of acute renal impair:Han patients were higher than Uyghur,adult were higher than children,the large BMI were higher than small BMI,the large body surface area were higher than small ones.Conclusion When use HD-MTX in clinic,we should pay more attention to the factors that ethnic,age,body surface area,BMI,combined with chemotherapy,the number of courses,dosage of methotrexate,chemotherapy before liver function or blood routine,and to decrease the incidence of adverse drug reactions.关键词
淋巴系肿瘤/大剂量甲氨蝶呤/药物不良反应/影响因素Key words
lymphatic tumor/high dose methotrexate/adverse drug reaction/influencing factor分类
医药卫生引用本文复制引用
徐蕊,王捷,李静,杨欢杰,陈渤松,袁园,赵军..大剂量甲氨蝶呤治疗淋巴系统肿瘤的药物不良反应影响因素分析[J].中国临床药理学杂志,2017,33(22):2239-2242,4.基金项目
新疆维吾尔自治区卫生厅青年科技人才专项科研基金资助项目(2014Y23) （2014Y23）
