张文娟 1苑晓超 1李志红 1夏丽芳 1李瑞雪 1尹飞1
作者信息
- 1. 071000 河北省保定市第一中心医院内分泌二科
- 折叠
摘要
Abstract
Objective To assess the impact of maternal thyroid peroxidase antibody (TPOAb)levels on neonatal thyroid function. Methods A total of 33 maternal women,who were positive for TPOAb alone,admitted to the Baoding First Central Hospital between January 2015 and June 2016,and met the inclusion criteria,were enrolled as a TPOAb-positive group. Thirty healthy pregnant women who deliveredat the same hospital during the same period were also recruited as a TPOAb -negative group. All maternal women were followed up until 6 months after delivery. Neonates were assigned into N (negative maternal TPOAb)or A (positive maternal TPOAb)groups according to maternal TPOAb levels during late pregnancy. The neonates in group A were further sub-divided into A1 (TPOAb level,30-100 U/ ml,n = 21)and A2 (TPOAb level, >100 U/ ml,n = 12)subgroups according to maternal TPOAb levels during late pregnancy. Data regarding the assessment of neonatal birth were compared between N and A groups,and thyroid function and thyroid antibodies were tested and compared between neonates in group N and subgroups A1 and A23-5 days after birth and between subgroups A1 and A21 and 3 months after birth,including thyroid-stimulating hormone (TSH),free thyroxine (FT 4 ),TPOAb,thyroglobulin antibody (TGAb) and thyroglobulin (TG). In addition,the association of TSH and FT 4 levels with age and TPOAb level,were also examined in maternal women positive for TPOAb 3-5 days after delivery. Results There were no significant differences in Apgar score 1 min after birth,body length or body weight between groups N and A (P > 0. 05). Serum TSH,TPOAb,TGAb and TG levels were all significantly greater in subgroups A1 and A2 than in group N 3-5 days after birth (P < 0. 05). FT 4 levels were significantly lower in subgroups A1 and A2 than in group N (P < 0. 05),while TSH,TPOAb,TGAb and TG levels were significantly higher in subgroup A2 than in subgroup A1. FT4 levels were significantly lower in subgroup A2 than in subgroup A1 (P < 0. 05). There were four lost to follow-up in subgroup A11 month after birth. There was no significant difference in neonatal FT4 levels between subgroups A1 and A21 month after birth (P > 0. 05),and significantly higher neonatal TSH,TPOAb,TGAb and TG levels were detected in subgroup A2 than in subgroup A11 month after birth (P < 0. 05). In addition,there were two neonates lost follow-up in subgroup A13 months after birth. There was no significant difference in neonatal FT4 ,TPOAb or TG levels between subgroups A1 and A23 months after birth (P > 0. 05),and significantly higher neonatal TSH and TGAb levels were detected in subgroup A2 than in subgroup A13 months after birth (P < 0. 05). Pearson correlation analysis revealed that neonatal TSH and FT4 levels 3-5 days after birth were positively correlated with maternal TPOAb levels (r = 0. 393 and 0. 423,P < 0. 05 in each case). Conclusion Maternal positive TPOAb influences neonatal thyroid functions and a higher maternal TPOAb level exhibits a longer effect on neonatal thyroid function.关键词
妊娠/甲状腺过氧化物酶抗体/甲状腺功能试验/婴儿Key words
Pregnancy/Thyroid peroxidase antibody/Thyroid function tests/Infant分类
医药卫生
