周玉玲 1邱春娟 1武晋晓 1焦秀敏 1张星光 1吕肖锋1
作者信息
- 1. 100700 北京市,陆军总医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the changes of spontaneous brain activity in newly diagnosed type 2 diabetes mellitus (T2DM)with different fasting plasma glucose (FPG)levels by resting-state functional magnetic resonance imaging (rs-fMRI),and based this,to explore the possible relationship between these changes and cognitive function. Methods We selected 41 newly diagnosed T2DM patients from Department of Endocrinology of Army General Hospital from July 2014 to October 2015 and divided them into mild hyperglycaemia group (group A,n = 21,7. 0 mmol/ L≤FPG < 11. 1 mmol/ L),and severe hyperglycemia group (group B,n = 20,FPG ≥11. 1 mmol/ L) based on the FPG levels measured on admission. Other 21 healthy controls were selected as the healthy control group. The clinical data of all the participants were collected. Cognitive function assessment and rs-fMRI (fALFF values)examination were preformed. Pearson correlation analysis was conducted to investigate the relationship of aberrant brain fALFF values with the clinical data and cognitive function score. Results Serum FPGand HbA1c levels were lower in healthy control group C compared with groups A and B (P < 0. 01),and they were higher in group B than in group A (P < 0. 01). There was no significant difference between the three groups in terms of cognitive function score (P > 0. 05). The fALFF values in bilateral superior frontal gyrus,posterior cingulate cortex/ precuneus,inferior parietal lobule and medial prefrontal cortex were found to be higher than the whole brain fALFF values in all groups (P < 0. 05) . Compared with groups A and B,group C had higher fALFF values in left frontal gyrus,right middle occipital gyrus,right posterior cerebellar lobe and left precentral gyrus but lower fALFF values in right superior frontal gyrus (P < 0. 05,FDR correction). fALFF values of left middle frontal gyrus in group B was higher than group A,fALFF values of right precentral gyrus in group B was lower than group A (P < 0. 05). The fALFF values in the right cerebellum posterior lobe were negatively correlated with HOMA-IR (r =-0. 470,P < 0. 05)and HbA 1c (r =-0. 348,P < 0. 05)in T2DM patients. The fALFF values in the right precentral gyrus were negatively correlated with HbA1c (r =-0. 518,P < 0. 05)and FPG (r =-0. 528,P< 0. 05)in T2DM patients,while those in the left middle frontal gyrus were positively correlated with HbA 1c (r = 0. 640,P <0. 05)and FPG (r = 0. 738,P < 0. 05). Conclusion In T2DM patients received initial diagnosis,decreased spontaneous neural activity were found in the right cerebellum posterior lobe,right middle occipital gyrus and so on in the early phase of T2DM;changes in fALFF values in partial brain regions are closely related to blood sugar control or insulin resistance,which provide insights into the neurological pathophysiology of cognitive impairments in T2DM.关键词
糖尿病,2型/认知障碍/静息态功能磁共振成像Key words
Type 2 diabetes/Cognition disorders/Resting-state functional magnetic resonance imaging分类
医药卫生
