中国全科医学2017，Vol.20Issue(36)：4591-4597,7.DOI:10.3969/j.issn.1007-9572.2017.00.149
高原低氧应激条件下促肾上腺皮质激素释放激素对免疫细胞作用机制的研究进展
Recent Advances in the Mechanism of Action of CRH on Immune Cells under Conditions of High Altitude Hypoxia
摘要
Abstract
Corticotrophin releasing hormone (CRH)is a biomarker of stress injury due to acute high altitude hypoxia. In this paper,the role of CRH in immune regulation under conditions of high altitude hypoxia was explored in order to provide a theoretical basis for the study of altitude sickness. We selected 68 articles meeting the inclusion criteria of this study by searching PubMed database using key words of " CRH High altitude" and " CRH Immune Cell" included in MeSH,and the databases of CNKY and WANFANG DATA using key words of " 促肾上腺皮质激素释放激素" and " 免疫细胞" . Based on the review of these articles,we concluded that,CRH can inhibit the immune system under conditions of high altitude hypoxia, which provides a theoretical basis for improving the diagnosis and treatment of immune system diseases under conditions of high altitude hypoxia.关键词
促肾上腺皮质激素释放激素/高原病/免疫细胞/p53Key words
Corticotrophin releasing hormone/Altitude sickness/Immune cells/p53分类
医药卫生引用本文复制引用
李文华,范卫捷,张群辉,任军..高原低氧应激条件下促肾上腺皮质激素释放激素对免疫细胞作用机制的研究进展[J].中国全科医学,2017,20(36):4591-4597,7.基金项目
国家自然科学基金资助项目(81360299,81760332) （81360299,81760332）
2015国家级大学生创新创业训练计划资助项目(201510695012) （201510695012）
