中国现代医学杂志2018，Vol.28Issue(2)：37-41,5.DOI:10.3969/j.issn.1005-8982.2018.02.007
结肠癌组织中ERRα 和ERRβ的表达水平及其临床意义
Expressions of ERRα and ERRβ in colon cancer tissue and their clinical significance
摘要
Abstract
Objective To detect the expressions of estrogen-related receptor α (ERRα) and ERRβ in colon cancer, evaluate their relationships with the clinicopathological characteristics and discuss the clinical significance. Methods Colon cancer tissues and para-cancerous normal tissues were selected from 63 patients. Western blot was used to detect the expressions of ERRα and ERRβ and their correlations with clinicopathological characteristics were observed. Results ERRα and ERRβ were expressed in the nuclei of the colon cancer tissues and the para-cancerous tissues, high expression was observed in the cancer tissues and low expression was seen in the para-cancerous tissues. The positive expression rates of ERRα and ERRβ in the colon cancer tissues were higher than those in the para-cancerous tissues (P < 0.05). The positive expressions of ERRα and ERRβ proteins were correlated with the deepth of tumor invasion, distant metastasis, blood vessel infiltration, TNM stage and tumor differentiation (P < 0.05). Spearman rank analysis showed the positive expression rates of ERRα and ERRβ proteins were positively correlated (P < 0.05). Conclusions ERRα and ERRβ are highly expressed in colon cancer tissues and correlated with the clinicopathological characteristics of poor prognosis. They may modulate the malignant behavior of colon cancer together.关键词
结肠癌/ERRα/ERRβKey words
colon cancer/estrogen-related receptor α/estrogen-related receptor β分类
医药卫生引用本文复制引用
刘海宏,石刚,张睿..结肠癌组织中ERRα 和ERRβ的表达水平及其临床意义[J].中国现代医学杂志,2018,28(2):37-41,5.基金项目
国家自然基金(No:81672427) （No:81672427）
