中国现代医学杂志2018，Vol.28Issue(2)：42-46,5.DOI:10.3969/j.issn.1005-8982.2018.02.008
MMP-7、MMP-9基因多态性与结直肠癌发病的关系研究
Correlations of MMP7 and MMP9 gene polymorphisms with incidence of colorectal cancer
摘要
Abstract
Objective To investigate the associations of CEA, CA199, MMP7 gene -181A/G polymorphism, MMP9 gene P574R polymorphism with the incidence of colorectal cancer. Methods A total of 500 cases of healthy physical examination were raised and divided into high-expression group and normal group according to the serum levels of CEA and CA199, and the incidence of colorectal cancer was statistically detected. Polymerase chain reaction restriction fragment length polymorphism was used to analyze the frequency of MMP7 gene -181A/G and MMP9 gene P574R single nucleotide polymorphisms (SNPs). And the correlations of the SNPs with clinical indexes were analyzed. Results The incidence of colorectal cancer in the high-expression group was higher than that in the normal group (P < 0.05) and the patients with MMP7 GG +AG genotype were more in the high-expression group than in the normal group (P < 0.05). G allele frequency in the high-expression group was higher than that in the normal group (P < 0.05). There was no obvious difference in the MMP9 PP or PR+RR genotype expression between the two groups (P > 0.05). The frequency of MMP7 GG+AG genotype in colorectal cancer patients was higher than that in the healthy people (P < 0.05), while the frequency of MMP9 PR+RR or PP genotype was not significantly different between the patients and the healthy people (P > 0.05). MMP7 and MMP9 gene polymorphisms were associated with TNM staging and lymphatic metastasis (P < 0.05). Conclusions CA199 and CEA have some clinical value in early diagnosis of colorectal cancer. MMP7-181 GG+AG and MMP9 P574R PP genotypes may be related to the occurrence and development of colorectal cancer.关键词
基质金属蛋白酶-7/基质金属蛋白酶-9/单核苷酸多态性/结直肠癌Key words
matrix metalloproteinase 7/matrix metalloproteinase 9/single nucleotide polymorphism/colorectal cancer分类
医药卫生引用本文复制引用
魏双琴,李迎春,张成,徐继,金丽雯..MMP-7、MMP-9基因多态性与结直肠癌发病的关系研究[J].中国现代医学杂志,2018,28(2):42-46,5.基金项目
上海市浦东新区科技发展基金(No:PKJ2015-Y31) （No:PKJ2015-Y31）
