中国现代医学杂志2018，Vol.28Issue(2)：65-68,4.DOI:10.3969/j.issn.1005-8982.2018.02.013
树突状细胞在儿童变应性哮喘中的表达及意义
Expression of dendritic cells in children with allergic asthma and its significance
摘要
Abstract
Objective To investigate the role of dendritic cells (DCs) in the pathogenesis of allergic asthma in children. Methods The control group and the observation group were respectively established for healthy children and children with allergic asthma. The data of airway mucosa associated lymph nodes of the two groups were collected at the onset of the disease and remission. The expressions of CD80 and CD86 on DCs were detected by immunohistochemical technique. ELISA was used for detection of changes of IL-4, IL-10 and IL-12 content in cell supernatant. Results The value of CD80 was statistically different between the observation group and the control group (P < 0.05). The IL-4, IL-10 and IL-12 levels in the observation group were significantly different from those in the control group (P < 0.05). After treatment remission, there was no significant difference in the phenotype or cytokine profile of DCs in the airway mucosa associated lymph nodes between the children with allergic asthma and the healthy controls (P > 0.05). Conclusions In children with allergic asthma, the phenotypic expression of dendritic cells and their secretory cytokines affect the occurrence and progression of the disease. Allergic asthma in children can be treated and prevented by interfering with the expression of dendritic cells.关键词
树突状细胞/变应性哮喘/超敏反应/细胞因子Key words
dendritic cell/allergic asthma/hypersensitivity/cytokine分类
医药卫生引用本文复制引用
刘璟,田冰..树突状细胞在儿童变应性哮喘中的表达及意义[J].中国现代医学杂志,2018,28(2):65-68,4.基金项目
重庆市万州区科委自然科学基金(No:201403052) （No:201403052）
