中国现代医学杂志2018，Vol.28Issue(2)：73-77,5.DOI:10.3969/j.issn.1005-8982.2018.02.015
表观扩散系数评价骨肉瘤化疗疗效的价值
Value of apparent diffusion coefficient in evaluation of curative effect of chemotherapy for osteosarcoma
王林 1吴学建 1王顺利 2史迎宾2
作者信息
- 1. 郑州大学第一附属医院 创伤骨科,河南 郑州 450052
- 2. 河南省郑州市骨科医院 骨肿瘤科,河南 郑州 450052
- 折叠
摘要
Abstract
Objective To investigate the application value of apparent diffusion coefficient (ADC) in monitoring the effect of neoadjuvant chemotherapy for osteosarcoma. Methods Twenty-eight osteosarcoma patients underwent MRI before and after the neoadjuvant chemotherapy. ADC values of the lesions were measured before and after treatment. The differences in ADC values before and after treatment in responders and non-responders were analyzed. Results After the neoadjuvant chemotherapy, 21 patients and 7 patients were categorized into the responder group and the non-responder group respectively. The mean pre-treatment ADC values of the responder group and the non-responder group were (1.12 ± 0.16)×10-3 mm2/s and (1.57 ± 0.20)×10-3 mm2/s, respectively. The mean post-treatment ADC values of the responder group and the non-responder group were (2.33 ± 0.18)×10-3 mm2/s and (1.97 ± 0.22)×10-3 mm2/s respectively. The differences in the ADC values between the two groups before and after chemotherapy were statistically different (P < 0.05). The difference in the rates of change of ADC values in the responder and non-responder groups before and after treatment was significant (P < 0.05). Conclusions ADC values enable a good short-term response evaluation for osteosarcoma and the pre-treatment ADC value indicates significant predictive value for responses to the treatment.关键词
表观扩散系数/骨肉瘤/治疗效果监测Key words
apparent diffusion coefficient/osteosarcoma/therapeutic monitoring分类
医药卫生引用本文复制引用
王林,吴学建,王顺利,史迎宾..表观扩散系数评价骨肉瘤化疗疗效的价值[J].中国现代医学杂志,2018,28(2):73-77,5.
