中国现代医学杂志2018，Vol.28Issue(2)：113-116,4.DOI:10.3969/j.issn.1005-8982.2018.02.025
OPN与AL患者临床特征及预后的关系
Correlations of osteopontin with clinical characteristics and prognosis of primary systemic amyloidosis
陈玉祯 1谭雪红 1卓雪芽 1叶桂样 1黄声淳 1陈胜男 1谭顺莲1
作者信息
- 1. 广东省佛山市中医院 检验医学中心,广东 佛山 528000
- 折叠
摘要
Abstract
Objective To investigate the correlations of serum osteopontin (OPN) level with clinical characteristics and prognosis of primary systemic amyloidosis (AL). Methods In this study, 60 patients with AL (AL group) treated in our hospital between March 2005 and March 2015 were enrolled. The OPN levels in the AL patients with different clinical features were analyzed. Meanwhile, 60 healthy subjects having health examination during the same period were selected as the control group. The levels of OPN and troponin t (cTnT) in the two groups were compared. Also, the correlation analysis between OPN level and cTnT level was conducted. After autologous stem cell transplantation, the levels of OPN and cTnT in the AL patients with different prognosis were detected. Results The OPN levels were significantly different in the AL patients with different glomerular filtration rate, number of organs involved, NYHA (New York Heart Association) classification grade of heart function, speed of mitral annular contraction, ejection fraction, cardiac mass index and diameter of left atrium (P < 0.05). The levels of OPN and cTnT in the AL group were higher than those in the control group (P < 0.05). Moreover, the OPN level showed a positive correlation with cTnT level (P < 0.05). Conclusions The level of OPN is related to the clinical characteristics and prognosis of primary systemic amyloidosis, and has important clinical value in the diagnosis and prognostic evaluation of the disease.关键词
骨桥蛋白/肌钙蛋白/原发性系统性淀粉样变Key words
osteopontin/cardiac troponin t/primary systemic light-chain amyloidosis分类
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陈玉祯,谭雪红,卓雪芽,叶桂样,黄声淳,陈胜男,谭顺莲..OPN与AL患者临床特征及预后的关系[J].中国现代医学杂志,2018,28(2):113-116,4.
