中国医学前沿杂志（电子版）2017，Vol.9Issue(10)：15-20,6.DOI:10.12037/YXQY.2017.10-03
免疫系统人源化小鼠模型的建立、应用及挑战
The establishment, application and challenge of the humanized mice
李爽 1邹建玲 1鲁智豪 1沈琳1
作者信息
- 1. 北京大学肿瘤医院暨北京市肿瘤防治研究所 消化肿瘤内科 恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142
- 折叠
摘要
Abstract
Cancer is a major burden of disease worldwide. Animal model plays an important role in the preclinical anti-tumor drug evaluation system. Despite the huge amount of advancement obtained from mouse studies, there are limitations to mouse models when investigating human biology. Several components of mouse biological systems are incongruent with those of humans, particularly their immune system. Animal models with human immune system are needed to mimicthe complexity of human tumor microenvironment. Humanized mice are defined as immunodeficient mice that have been engrafted with human hematopoietic cells, lymphocytes or tissues that generate a functional human immune system. Human tumor cells or tissue are engrafted in humanized mice to examine xenograft growth in the context of a human immune system, to assess the efficacy of immunotherapy and explore mechanisms.关键词
免疫检查点抑制剂/免疫治疗/小鼠模型/人源化小鼠/肿瘤微环境Key words
Checkpoint blocker/Immunotherapy/Murine model/Humanized mice/Tumor micro en-vironment引用本文复制引用
李爽,邹建玲,鲁智豪,沈琳..免疫系统人源化小鼠模型的建立、应用及挑战[J].中国医学前沿杂志（电子版）,2017,9(10):15-20,6.
