中国医院用药评价与分析2017，Vol.17Issue(11)：1484-1485,1488,3.DOI:10.14009/j.issn.1672-2124.2017.11.013
注射用骨肽联合阿仑膦酸钠片治疗原发性骨质疏松症的疗效观察
Observation on Efficacy of Ossotide for Injection Combined with Alendronate Tablets in Treatment of Primary Osteoporosis
应小柏 1涂琦1
作者信息
- 1. 湖北省荣军医院骨外科,湖北武汉 430000
- 折叠
摘要
Abstract
OBJECTIVE:To probe into the efficacy of ossotide for injection combined with Alendronate tablets in treatment of primary osteoporosis .METHODS: 100 patients with primary osteoporosis admitted into Hubei Rongjun Hospital from Jan.2014 to Jan.2017 were selected and divided into observation group and control group via random number table, with 50 cases in each.The control group was treated with Calcium carbonate and vitamin D 3 tablets, while the observation group was given ossotide for injection combined with Alendronate tablets based on the control group.Both groups were given a 6-month treatment.Clinical efficacy,bone density and pain scoring before and after treatment , and incidences of adverse drug reactions between two groups were compared .RESULTS:The total effective rate of observation group (94％, 47/50) was significantly higher than that of the control group (78％, 39/50), with statistically significant difference (P<0.05);after treatment, the average bone density of observation group [(0.824 ± 0.065) g/cm2 ] was significantly higher than that of the control group [(0.781 ±0.059) g/cm2 ], with statistically significant difference (P<0.05);after treatment, the average pain scoring of observation group [(2.83 ±0.86) scores] was significantly lower than that of the control group [ ( 3.92 ±1.05 ) scores ] , with statistically significant difference ( P<0.05 ); the incidences of adverse drug reactions of observation group and control group were respectively 8％(4/50) and 2％(1/50), the difference had no statistical significance (P>0.05).CONCLUSIONS: The efficacy of ossotide for injection combined with Alendronate tablets in treatment of primary osteoporosis is remarkable , which can increase patients bone densities and relieve pain , with high safety .关键词
原发性骨质疏松症/阿仑膦酸钠/注射用骨肽Key words
Primary osteoporosis/Alendronate/Ossotide for injection分类
医药卫生引用本文复制引用
应小柏,涂琦..注射用骨肽联合阿仑膦酸钠片治疗原发性骨质疏松症的疗效观察[J].中国医院用药评价与分析,2017,17(11):1484-1485,1488,3.
